{"id":"W4400533637","doi":"10.1097/qad.0000000000003938","title":"Local microbiota dysbiosis contributes to the development of high-risk human papillomavirus-associated anal squamous cell carcinoma","year":2024,"lang":"en","type":"letter","venue":"AIDS","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre","funders":"","keywords":"Dysbiosis; Human papillomavirus; Basal cell; Biology; Medicine; Cancer research; Immunology; Internal medicine; Gut flora","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005864861,0.0003940835,0.0008872254,0.0003367312,0.0002236806,0.0000606435,0.0004857772,0.0006903108,0.001500995],"category_scores_gemma":[0.00009587818,0.0002646568,0.0002997331,0.0007219369,0.0001967763,0.00001612804,0.000399098,0.002281055,0.0003504236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007661499,"about_ca_system_score_gemma":0.000575537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002358621,"about_ca_topic_score_gemma":0.0008695166,"domain_scores_codex":[0.9970742,0.0001798785,0.0006998776,0.0005904716,0.000748118,0.0007074314],"domain_scores_gemma":[0.998394,0.0002957765,0.0001377339,0.0006182691,0.0004059933,0.0001482272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001232938,0.0001216054,0.006262856,0.0008114002,0.0003865432,0.0001721707,0.0004328972,8.523131e-7,0.001632687,0.00001321779,0.9793177,0.01072479],"study_design_scores_gemma":[0.002699873,0.00154431,0.1500992,0.0001783421,0.001184231,0.000006007762,0.0001625236,0.000008135346,0.04258914,0.0001139192,0.8009162,0.0004980926],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6548447,0.005876147,0.0003539999,0.3260672,0.001082547,0.002441932,0.001817681,0.0001700574,0.007345695],"genre_scores_gemma":[0.9047878,0.0000153022,0.0001004121,0.08775128,0.0007396757,0.00007930763,0.0008899029,0.00008147928,0.005554875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.249943,"threshold_uncertainty_score":0.9999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972129162820489,"score_gpt":0.2827056399824646,"score_spread":0.2629843483542597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}