{"id":"W4400545487","doi":"10.1111/exd.15130","title":"Increased loss‐of‐function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta‐analysis","year":2024,"lang":"en","type":"review","venue":"Experimental Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; Janssen Pharmaceuticals; LEO Pharma; Regeneron Pharmaceuticals; Sanofi; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Filaggrin; Atopic dermatitis; Population; Demography; Medicine; Genetics; Biology; Immunology; Environmental health","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001456499,0.0005782714,0.005843315,0.0004976339,0.00006906148,0.0000244106,0.0002041927,0.000383534,0.0001630894],"category_scores_gemma":[0.0001197984,0.0004285398,0.001003582,0.0007827941,0.0002803065,0.000111899,0.0001584385,0.000271325,0.00007956945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009862302,"about_ca_system_score_gemma":0.0001275743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005253571,"about_ca_topic_score_gemma":0.00005954308,"domain_scores_codex":[0.9961622,0.0008889201,0.001712642,0.0006247844,0.0002806081,0.0003308296],"domain_scores_gemma":[0.9983308,0.0002297191,0.0007689334,0.0004446988,0.0000862239,0.0001395762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000005964391,0.0003408634,0.01035265,0.9506094,0.03755153,0.0005799453,0.0002904285,3.671908e-7,3.396165e-7,0.000009579024,0.00007444288,0.0001844933],"study_design_scores_gemma":[0.0008123977,0.0000892173,0.007366948,0.06747781,0.9194576,0.003605933,0.00008483623,0.00002300337,0.00008679406,0.0000390086,0.0003670863,0.0005894046],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0128506,0.9837556,0.00001364725,0.00004467709,0.00006841373,0.002975265,0.0002239468,0.0000517085,0.0000161607],"genre_scores_gemma":[0.2110596,0.7863406,0.00006236928,0.000238391,0.000006714724,0.001584915,0.0006424878,0.00003871713,0.00002619888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8831316,"threshold_uncertainty_score":0.9998167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244424943602404,"score_gpt":0.3365834843088479,"score_spread":0.3141392348728239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}