{"id":"W4400549426","doi":"10.1021/acscatal.4c02811","title":"Anionic Olefin Metathesis Catalysts Enable Modification of Unprotected Biomolecules in Water","year":2024,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Norges Forskningsråd","keywords":"Carbene; Catalysis; Chemistry; Nucleophile; Metathesis; Cationic polymerization; Combinatorial chemistry; Organic chemistry; Salt metathesis reaction; Ligand (biochemistry); Polymerization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348375,0.0003621577,0.0001575387,0.0001545845,0.0001122667,0.0003302648,0.0002235429,0.0002689625,0.001338219],"category_scores_gemma":[0.0002035494,0.0001626032,0.0001481694,0.0001404105,0.0002159037,0.000329624,0.0002884939,0.0004255849,0.000451156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849568,"about_ca_system_score_gemma":0.0001535009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002763683,"about_ca_topic_score_gemma":0.0005763238,"domain_scores_codex":[0.9998838,0.00001360627,0.000006442421,0.00002732769,0.00004355671,0.0000253481],"domain_scores_gemma":[0.999928,0.00001635101,0.00002256199,0.00001158223,0.0000101886,0.00001139718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001813827,0.0000047811,0.00005523601,0.00002634246,0.000002373466,0.000026675,0.000008545747,0.00006851554,0.9966254,0.0003641869,0.00003395516,0.002765777],"study_design_scores_gemma":[0.000002129746,0.00004086096,0.0001481645,0.000001584524,0.000002549537,0.00004944318,0.000004382159,0.0002465218,0.9978449,0.00004897749,0.001608874,0.000001631949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642518,0.002352767,0.02389085,0.000166006,0.00005457324,0.00005228465,0.0002048267,0.0004318329,0.008595031],"genre_scores_gemma":[0.9904585,0.0008264977,0.00484374,0.00003638713,0.000009094188,0.00001538583,0.0001032729,0.00003698676,0.0036701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338219,"threshold_uncertainty_score":0.004476786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813989095624149,"score_gpt":0.272943515591325,"score_spread":0.2548036246350835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}