{"id":"W4400549426","doi":"10.1021/acscatal.4c02811","title":"Anionic Olefin Metathesis Catalysts Enable Modification of Unprotected Biomolecules in Water","year":2024,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Norges Forskningsråd","keywords":"Carbene; Catalysis; Chemistry; Nucleophile; Metathesis; Cationic polymerization; Combinatorial chemistry; Organic chemistry; Salt metathesis reaction; Ligand (biochemistry); Polymerization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005141552,0.0002272756,0.0003837186,0.0002099606,0.00003544527,0.00004803608,0.0003797726,0.0001887516,0.0007412768],"category_scores_gemma":[0.0002702207,0.0001862182,0.000173414,0.000794965,0.00009049855,0.0001155354,0.0001137127,0.0001831541,0.0001155623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732247,"about_ca_system_score_gemma":0.00007361819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004633661,"about_ca_topic_score_gemma":0.00002815853,"domain_scores_codex":[0.9982471,0.00005099246,0.000531903,0.0005546472,0.0002935248,0.0003218423],"domain_scores_gemma":[0.9987288,0.0001821448,0.00007694262,0.0008865034,0.00006276748,0.00006281414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009900631,0.00008280379,0.00004394897,0.0004105809,0.000198601,0.00001914698,0.0009487656,0.00001618043,0.9905968,0.00003521649,0.00003496445,0.007603069],"study_design_scores_gemma":[0.0001517354,0.000003659656,0.00001856218,0.00009953728,0.0002596506,0.00001863797,0.0003718778,0.0006343152,0.9972376,0.0004516225,0.0005384999,0.0002143129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940556,0.001376843,0.0005179712,0.0003658137,0.00004481391,0.00007894421,0.00003691868,0.0001659941,0.003357087],"genre_scores_gemma":[0.9967906,0.00005197232,0.001400538,0.000005920152,0.00004404908,0.00006627803,0.0003162108,0.00005019316,0.001274243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007388756,"threshold_uncertainty_score":0.8116461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813989095624149,"score_gpt":0.272943515591325,"score_spread":0.2548036246350835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}