{"id":"W4400567199","doi":"10.21037/tau-24-20","title":"Combination of PARP and DNA methylation inhibitors as a potential personalized therapy for SETD2-mutated clear-cell renal cancers","year":2024,"lang":"en","type":"letter","venue":"Translational Andrology and Urology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Methylation; DNA; Poly ADP ribose polymerase; Cancer research; Cell; Bioinformatics; Genetics; Computational biology; Biology; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007475669,0.0003452076,0.0008379279,0.0003002901,0.0009530222,0.0009136908,0.0005229615,0.01049435,0.002920778],"category_scores_gemma":[0.004551324,0.0002111577,0.0008111596,0.0002406927,0.0006525111,0.001008536,0.0004181756,0.009397303,0.001786013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001686241,"about_ca_system_score_gemma":0.001196252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001724266,"about_ca_topic_score_gemma":0.004123845,"domain_scores_codex":[0.9995054,0.0001373488,0.0000673051,0.00005141941,0.0001601371,0.00007839836],"domain_scores_gemma":[0.9988437,0.000688374,0.00007314869,0.00003098224,0.0001446003,0.0002192761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005935626,0.0002342184,0.003959489,0.0002394583,0.00009346422,0.02326316,0.0001316587,0.0009104406,0.002307604,0.005834863,0.8549044,0.1075278],"study_design_scores_gemma":[0.0009285285,0.0006885447,0.00493364,0.0003221807,0.0001476965,0.04049103,0.000272665,0.004235737,0.00233196,0.02324906,0.9223115,0.00008748372],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.006389481,0.007355054,0.0007414317,0.961613,0.01521096,0.00004426413,0.0002009087,0.00009318974,0.008351638],"genre_scores_gemma":[0.07121959,0.009902652,0.002049672,0.8289157,0.06733616,0.0001392349,0.0002257508,0.00004543715,0.02016585],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01049435,"threshold_uncertainty_score":0.01223463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613622751466348,"score_gpt":0.261480359431751,"score_spread":0.2453441319170875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}