{"id":"W4400570145","doi":"10.1101/2024.07.10.602937","title":"Evolutionary and functional divergence of Sfx, a plasmid-encoded H-NS homolog, underlies the regulation of IncX plasmid conjugation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; Universities Space Research Association; Ohio State University","keywords":"Plasmid; Biology; Bacterial conjugation; Psychological repression; Genetics; Functional divergence; DNA; Gene; Cell biology; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351632,0.0002769215,0.000201799,0.000260141,0.0001348079,0.0002735789,0.0001752742,0.0002448451,0.0006166362],"category_scores_gemma":[0.000190031,0.0001055148,0.0002117327,0.0002168825,0.0002381231,0.0002145943,0.000349178,0.000419103,0.0003097606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270991,"about_ca_system_score_gemma":0.0001327025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003802257,"about_ca_topic_score_gemma":0.0003034596,"domain_scores_codex":[0.9998782,0.0000163702,0.00001014914,0.00003555091,0.00003879783,0.00002099495],"domain_scores_gemma":[0.9998423,0.0000256441,0.00005559781,0.00002695528,0.00002060314,0.00002894473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004723402,0.00001191614,0.002528408,0.00001579045,0.000003154304,0.00008154181,0.00002929654,0.00009762515,0.9952855,0.0001404983,0.000008240018,0.00175076],"study_design_scores_gemma":[0.000009397698,0.0003768277,0.1620844,0.00001127566,0.00002100329,0.001852788,0.0002131267,0.006136093,0.8256214,0.0003075828,0.003347306,0.00001894134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979723,0.000265639,0.001049463,0.00002256466,0.00000300587,0.000004857968,0.00007817306,0.00002215613,0.0005817654],"genre_scores_gemma":[0.9973265,0.0001556755,0.001082235,0.00001418133,0.000003266469,0.000006400439,0.0002646242,0.00001457881,0.001132506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006166362,"threshold_uncertainty_score":0.002062857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009962631288618897,"score_gpt":0.1983755911411113,"score_spread":0.1884129598524923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}