{"id":"W4400573483","doi":"10.1093/jbmr/zjae104","title":"Calorie restriction in mice impairs cortical but not trabecular peak bone mass by suppressing bone remodeling","year":2024,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Endocrinology; Internal medicine; Cortical bone; Osteoblast; Bone resorption; Bone marrow; Adipocyte; Bone mineral; Adipogenesis; Bone remodeling; Chemistry; Osteoclast; Adipose tissue; Osteoporosis; Medicine; In vitro; Anatomy; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003841448,0.00122083,0.0007040231,0.001873524,0.0004292345,0.0007666218,0.000768245,0.001196103,0.004214051],"category_scores_gemma":[0.0001967,0.0007775982,0.0008207682,0.0006135976,0.0009862897,0.0005058841,0.0005735245,0.002155384,0.0009924845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005541589,"about_ca_system_score_gemma":0.0005298139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002247649,"about_ca_topic_score_gemma":0.003514777,"domain_scores_codex":[0.9994412,0.00005522618,0.00007985675,0.0001779051,0.000100375,0.0001454465],"domain_scores_gemma":[0.9995567,0.00003224696,0.0001842447,0.00004916928,0.00002954996,0.0001481087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001327573,0.0003275006,0.0005590415,0.0001183242,0.00003271412,0.0001256106,0.00004735106,0.0001316722,0.9948147,0.0002381157,0.0001559381,0.002121448],"study_design_scores_gemma":[0.0006646025,0.003883125,0.04359657,0.0002107086,0.0003100505,0.00115293,0.000369898,0.003408736,0.9346216,0.0007816203,0.01092154,0.00007867975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863533,0.002306849,0.004050352,0.0005120667,0.00009177983,0.0001248939,0.003806571,0.0007406366,0.00201353],"genre_scores_gemma":[0.9691134,0.003449066,0.008165796,0.0005130242,0.00005277415,0.0007325939,0.003437865,0.0003667549,0.01416861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004214051,"threshold_uncertainty_score":0.01409739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05561676206985557,"score_gpt":0.3713613730921305,"score_spread":0.315744611022275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}