{"id":"W4400575204","doi":"10.1016/j.drugalcdep.2023.110213","title":"NMRA-140, a Novel and Selective Kappa Opioid Receptor Antagonist: Mode of Action Profiling Studies Demonstrate No Opioid Agonist Properties Implicated in Opioid-Related Abuse","year":2024,"lang":"en","type":"article","venue":"Drug and Alcohol Dependence","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Opioid; κ-opioid receptor; Kappa; Agonist; Pharmacology; Opioid receptor; Medicine; Receptor; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589169,0.0003902064,0.0005550763,0.0003528795,0.0003043935,0.0003473991,0.0004092267,0.0003849734,0.002703088],"category_scores_gemma":[0.0003004103,0.0002202306,0.0002086436,0.000156838,0.0003111511,0.0004362277,0.0002002518,0.0006304167,0.0007421892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752429,"about_ca_system_score_gemma":0.0006897377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007306353,"about_ca_topic_score_gemma":0.002086965,"domain_scores_codex":[0.9998399,0.00002006223,0.000009630456,0.0000369783,0.00004974532,0.00004369822],"domain_scores_gemma":[0.9998544,0.00003027384,0.00002569511,0.00001298691,0.00002942839,0.00004714054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002783533,0.00007840324,0.0001625216,0.00005046823,0.00001052324,0.00004985767,0.00001535518,0.00007821505,0.993564,0.0001330541,0.00009891589,0.005480357],"study_design_scores_gemma":[0.00007062536,0.003515383,0.006370592,0.00001979595,0.00007705318,0.001807315,0.00007632082,0.001354902,0.9793512,0.0001591593,0.007166004,0.00003169751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788604,0.004420979,0.007044223,0.0002124564,0.00004872699,0.0001578951,0.0008552199,0.0001863089,0.008213764],"genre_scores_gemma":[0.9768527,0.003728477,0.008848838,0.0004008094,0.00004726819,0.0001164962,0.001794991,0.00007194744,0.008138469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703088,"threshold_uncertainty_score":0.009042799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05664522972042695,"score_gpt":0.3171793553216024,"score_spread":0.2605341256011754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}