{"id":"W4400580428","doi":"10.1530/rep-24-0171","title":"REPRODUCTIVE AGEING: Altered histone modification landscapes underpin defects in uterine stromal cell decidualization in aging females","year":2024,"lang":"en","type":"article","venue":"Reproduction","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Biotechnology and Biological Sciences Research Council; Alberta Children's Hospital Research Institute; Directorate for Biological Sciences","keywords":"Decidualization; H3K4me3; Biology; Epigenetics; Placentation; Transcriptome; Stromal cell; Histone; Embryo; Endocrinology; Cell biology; Internal medicine; Gene; Genetics; Gene expression; Cancer research; Pregnancy; Placenta; Medicine; Fetus; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190471,0.0001822679,0.0001735387,0.0003214813,0.0001141279,0.000200859,0.0001093841,0.0001807335,0.001402343],"category_scores_gemma":[0.0001046793,0.0001238187,0.0001867646,0.0001607164,0.0001972059,0.0001381417,0.0002132603,0.00024231,0.0001889752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112696,"about_ca_system_score_gemma":0.0001074498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005594395,"about_ca_topic_score_gemma":0.0008859251,"domain_scores_codex":[0.9999195,0.000007565251,0.000006612918,0.00002925469,0.00002090096,0.00001625391],"domain_scores_gemma":[0.9999111,0.000007260883,0.00004210109,0.000009259441,0.000008982734,0.00002142228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060257,0.000006088148,0.004153002,0.00002988104,0.00001023396,0.00006927795,0.0000365407,0.00002655013,0.9936157,0.00005822621,0.00004166339,0.001846798],"study_design_scores_gemma":[0.00001017812,0.0005033385,0.5947013,0.00002548324,0.00007646155,0.001865174,0.0002829732,0.0006668335,0.395916,0.0002505142,0.005685415,0.00001632587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922006,0.002889367,0.002470161,0.00007064288,0.00002173319,0.00001180266,0.001392053,0.00006061013,0.0008830916],"genre_scores_gemma":[0.9950971,0.001042179,0.0009904761,0.0001019736,0.00001111382,0.00001896215,0.0008581393,0.00001939069,0.001860637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402343,"threshold_uncertainty_score":0.004691303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366997853190221,"score_gpt":0.311246354504895,"score_spread":0.2775763759729928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}