{"id":"W4400582488","doi":"10.1158/1078-0432.ccr-24-0255","title":"Circulating Tumor DNA Dynamics Reveal <i>KRAS G12C</i> Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Roche (Canada)","funders":"National Center for Advancing Translational Sciences","keywords":"KRAS; Circulating tumor DNA; Cancer research; Mutation; Dynamics (music); DNA; Medicine; Biology; Cancer; Internal medicine; Genetics; Colorectal cancer; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344497,0.0002116846,0.000389161,0.0002812036,0.0001626277,0.0003099056,0.0001647009,0.0002269462,0.001172437],"category_scores_gemma":[0.0005348552,0.0001557582,0.000123119,0.0002172973,0.0002239837,0.0001725035,0.0001610203,0.0004005462,0.0001752643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003518623,"about_ca_system_score_gemma":0.0002007418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009898097,"about_ca_topic_score_gemma":0.001586829,"domain_scores_codex":[0.999866,0.00002666689,0.00001002095,0.00004732157,0.00002772013,0.00002222805],"domain_scores_gemma":[0.9996725,0.00006876829,0.0001313439,0.00001891491,0.00003702042,0.0000713528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01458583,0.0005806906,0.690523,0.000123419,0.0001712614,0.000248082,0.000230566,0.001236399,0.2338064,0.00004801558,0.0006440821,0.0578023],"study_design_scores_gemma":[0.0005290186,0.0100133,0.9396596,0.00001389568,0.0001712619,0.001166516,0.0002103552,0.00328779,0.04353506,0.0001028391,0.001294542,0.00001583928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993812,0.0002095343,0.0001108466,0.00001985149,0.00000208592,0.0000121259,0.0001054901,0.000009865907,0.0001488626],"genre_scores_gemma":[0.9993789,0.00005352815,0.0001884856,0.00002896047,0.000004599409,0.00001164074,0.0002047266,0.000002949686,0.0001260409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172437,"threshold_uncertainty_score":0.003922164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06284397043373981,"score_gpt":0.4447573396143443,"score_spread":0.3819133691806045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}