{"id":"W4400582752","doi":"10.1002/advs.202406473","title":"Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in <i>Candida Albicans</i>","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Key Research and Development Program of China; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Candida albicans; Autophagy; Cytotoxic T cell; Ergosterol; Blocking (statistics); Chemistry; Membrane; Antifungal; Corpus albicans; Cytotoxicity; Microbiology; Pharmacology; Biology; Biochemistry; In vitro; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003172943,0.0002139752,0.0002929296,0.0002776218,0.0001750477,0.0001048253,0.000148831,0.00006376938,0.00002010263],"category_scores_gemma":[0.000100303,0.0001886991,0.00004664203,0.001035784,0.0002969467,0.0005606625,0.00006500206,0.0002043303,0.00001027261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726179,"about_ca_system_score_gemma":0.0002044092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002782514,"about_ca_topic_score_gemma":0.000009937706,"domain_scores_codex":[0.9980764,0.00003541221,0.0002822501,0.0006640978,0.0004636504,0.0004782312],"domain_scores_gemma":[0.9992852,0.0001373298,0.00005147942,0.0002437796,0.00004085988,0.0002413531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478976,0.00006846593,0.0006684843,0.000323998,0.00001458428,0.0002918838,0.0002813367,0.001009991,0.973064,0.0001236784,0.00002781352,0.02397784],"study_design_scores_gemma":[0.001896229,0.0002447465,0.004749154,0.001116607,0.00003203551,0.0001082654,0.00003234772,0.05205811,0.9387857,0.0001191122,0.0006490531,0.0002086844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912914,0.004543108,0.002584464,0.0001492348,0.0004072421,0.0005478504,0.000007141534,0.0001618343,0.0003076998],"genre_scores_gemma":[0.9982045,0.0006116717,0.0003098015,0.000519901,0.00004709668,0.00003899472,0.000007686989,0.00002803046,0.0002323103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05104812,"threshold_uncertainty_score":0.7694927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003805591572800657,"score_gpt":0.2545132995037013,"score_spread":0.2507077079309007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}