{"id":"W4400582752","doi":"10.1002/advs.202406473","title":"Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in <i>Candida Albicans</i>","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Key Research and Development Program of China; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Candida albicans; Autophagy; Cytotoxic T cell; Ergosterol; Blocking (statistics); Chemistry; Membrane; Antifungal; Corpus albicans; Cytotoxicity; Microbiology; Pharmacology; Biology; Biochemistry; In vitro; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009455589,0.0002931721,0.0002641736,0.000204155,0.0001497871,0.00024063,0.0001952879,0.0002858563,0.001056184],"category_scores_gemma":[0.00007151723,0.00008094494,0.0002206385,0.0001291711,0.0001268789,0.0001289178,0.0001480704,0.0004219426,0.0002691482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001904003,"about_ca_system_score_gemma":0.0002757283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002372,"about_ca_topic_score_gemma":0.001600062,"domain_scores_codex":[0.9999257,0.00001288768,0.00001078061,0.00001016941,0.0000180518,0.00002245452],"domain_scores_gemma":[0.999964,0.000004930446,0.000009341782,0.000004295026,0.000006580372,0.00001091841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004245398,0.00007746404,0.0001443419,0.0001197481,0.00000840015,0.0001194661,0.00001100766,0.0001394418,0.9937831,0.0001378021,0.000232304,0.004802399],"study_design_scores_gemma":[0.00004281936,0.0007189421,0.001621899,0.00001114203,0.00001910996,0.0002349681,0.00001213111,0.0003875019,0.9939865,0.00003050709,0.002928324,0.000006276252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849157,0.006277127,0.00182286,0.0003282623,0.0001079078,0.00005164396,0.0006620124,0.0001523998,0.005682156],"genre_scores_gemma":[0.9933976,0.002535349,0.001318024,0.0001455105,0.00002165646,0.00002628889,0.0003553163,0.00001541441,0.002184861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056184,"threshold_uncertainty_score":0.003533304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003805591572800657,"score_gpt":0.2545132995037013,"score_spread":0.2507077079309007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}