{"id":"W4400583892","doi":"10.4049/jimmunol.2300154","title":"ICOS-expressing Regulatory T Cells Influence the Composition of Antitumor CTL Populations","year":2024,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Granzyme B; Perforin; CD8; Cytotoxic T cell; CTL*; Cancer research; Biology; T cell; Granzyme; Regulatory T cell; Immunology; Cell; Tumor progression; Immunotherapy; Tumor microenvironment; Immune system; Cancer; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608986,0.0003795895,0.0002696262,0.0002541717,0.00008820277,0.0003520957,0.0001445108,0.0002695637,0.001120428],"category_scores_gemma":[0.0001395733,0.0001164121,0.0001917969,0.00009562231,0.0002299842,0.0002700563,0.0001415953,0.0008185324,0.0002053818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507987,"about_ca_system_score_gemma":0.0001186822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343025,"about_ca_topic_score_gemma":0.0002584888,"domain_scores_codex":[0.9997841,0.00003045184,0.00002031781,0.00005358321,0.00003592881,0.0000757826],"domain_scores_gemma":[0.9997882,0.00003640826,0.00007022524,0.00001965822,0.00001671912,0.00006882185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392015,0.00002262871,0.0004260585,0.00001659513,0.000002085829,0.00001670031,0.000008346658,0.00003567028,0.9983696,0.00004666625,0.00001047533,0.0009058121],"study_design_scores_gemma":[0.00004345178,0.000745483,0.00879139,0.00001319225,0.00006033136,0.0002833785,0.00006913285,0.001173746,0.9870976,0.0001011519,0.001616038,0.000005180565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969482,0.0006709102,0.001312669,0.00003032064,0.0000190553,0.00001342255,0.0001006117,0.00004315774,0.0008617357],"genre_scores_gemma":[0.9975464,0.0003648188,0.0009491435,0.00004472698,0.00001660908,0.00002530021,0.0001770673,0.00002663432,0.0008491349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120428,"threshold_uncertainty_score":0.003748178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141848028552777,"score_gpt":0.2463500893472918,"score_spread":0.2321652864920141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}