{"id":"W4400588480","doi":"10.1038/s43018-024-00787-0","title":"Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer","year":2024,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; St. George's, University of London; Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; Cancer Research Institute; Royal Marsden NHS Foundation Trust; Department of Health and Social Care; Cancer Research UK; Canada's Michael Smith Genome Sciences Centre; National Institute for Health and Care Research; Directorate for Biological Sciences; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Orta Doğu Teknik Üniversitesi; Wellcome Trust","keywords":"Prostate cancer; Hazard ratio; Internal medicine; Oncology; Medicine; Confidence interval; Histopathology; Prostate; Clinical trial; Biochemical recurrence; Cancer; Pathology; Prostatectomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390716,0.0001797451,0.0001558698,0.0001421854,0.00003013289,0.00005022846,0.0001891721,0.0002649465,0.00008705336],"category_scores_gemma":[0.0001731067,0.0001814477,0.00007281222,0.0005960897,0.00005908994,0.00001056309,0.00008952797,0.0004424904,0.00001020936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003206838,"about_ca_system_score_gemma":0.0008027385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319847,"about_ca_topic_score_gemma":0.001041841,"domain_scores_codex":[0.9987187,0.00002134364,0.0002099391,0.0005342305,0.0001959669,0.0003197903],"domain_scores_gemma":[0.999454,0.0000292167,0.0000557764,0.0002383102,0.0001347165,0.00008798201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001383936,0.0001987565,0.03038431,0.0006539408,0.0002811213,0.0002210575,0.0004041756,0.0166721,0.1190698,0.00190189,0.2116453,0.6171836],"study_design_scores_gemma":[0.001173146,0.000282922,0.02146506,0.0004551475,0.00006055311,0.00000951595,0.00004602847,0.002041532,0.01944675,0.0005671025,0.9538778,0.0005744488],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5975138,0.395971,0.0002115937,0.0005959476,0.003377774,0.0005379902,0.0009322061,0.00004037709,0.0008193715],"genre_scores_gemma":[0.9812442,0.0157913,0.0002414261,0.0005920666,0.0006518522,0.0002475465,0.0001114106,0.00004054285,0.001079663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7422326,"threshold_uncertainty_score":0.7399222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003519574898260935,"score_gpt":0.2646021724613133,"score_spread":0.2610825975630524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}