{"id":"W4400588907","doi":"10.1038/s41556-024-01459-y","title":"Pressure sensing of lysosomes enables control of TFEB responses in macrophages","year":2024,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Toronto Metropolitan University; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Government of Canada","keywords":"Cell biology; TFEB; Chemistry; Lysosome; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003151504,0.0001315073,0.0002870339,0.0001431842,0.00001449509,0.00000622918,0.0001255405,0.000533687,0.00001888773],"category_scores_gemma":[0.0001721395,0.0001073756,0.0001158029,0.0001403315,0.0001442014,0.000001903749,0.00005005979,0.0002557775,0.00000155812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003037213,"about_ca_system_score_gemma":0.00007216981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003444234,"about_ca_topic_score_gemma":0.00001145051,"domain_scores_codex":[0.999002,0.0002011048,0.0002547401,0.000298333,0.00005752818,0.0001863279],"domain_scores_gemma":[0.9994817,0.0001314628,0.00007138073,0.0002143819,0.00007339217,0.00002763057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003024474,0.0000261746,0.0009630072,0.000146587,0.00006516001,0.00001006547,0.00004333519,0.00006213527,0.9955407,0.0003259517,0.0003414065,0.002172972],"study_design_scores_gemma":[0.0004723445,0.0001435422,0.0007384331,0.00004078398,0.00004822197,0.000008071728,0.00002480981,0.0001910469,0.9277202,0.000179042,0.07032955,0.0001039785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8486823,0.1500714,0.0002217596,0.0001124481,0.000374318,0.00009499575,0.0001219249,0.00001083738,0.0003100509],"genre_scores_gemma":[0.9980571,0.0007218505,0.0002986875,0.0001019675,0.0001678981,0.000001561825,0.00003865842,0.00001656915,0.0005957562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1493748,"threshold_uncertainty_score":0.4378648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004118092066652881,"score_gpt":0.2536954341282787,"score_spread":0.2495773420616259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}