{"id":"W4400595962","doi":"10.1186/s40478-024-01820-0","title":"Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Peer Reviewed Alzheimer’s Research Program; U.S. Army Medical Research and Development Command; Ministero dell'Università e della Ricerca; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Serotonergic; Hippocampus; Endocannabinoid system; Neuroscience; Medicine; Traumatic brain injury; Dementia; Neurology; Cognitive decline; Entorhinal cortex; Genetically modified mouse; Disease; Psychology; Receptor; Internal medicine; Biology; Transgene; Gene; Serotonin; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001949863,0.000986368,0.0006440541,0.001573819,0.0003452343,0.0005410418,0.0002583025,0.0007213586,0.001711021],"category_scores_gemma":[0.0001326251,0.0003502686,0.0004902586,0.0004695999,0.0005331003,0.0003714028,0.0003095241,0.001331644,0.0004434068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003441514,"about_ca_system_score_gemma":0.0002405768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079351,"about_ca_topic_score_gemma":0.001534333,"domain_scores_codex":[0.9997869,0.00001414177,0.00002291018,0.00006537293,0.00004487505,0.00006582776],"domain_scores_gemma":[0.9996474,0.0000127224,0.0001531703,0.00002116066,0.00004405137,0.0001215646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009441563,0.000144191,0.001244496,0.00005519386,0.0000259744,0.0001559969,0.00006378125,0.00002775152,0.9962631,0.00003852727,0.00004256616,0.0009941919],"study_design_scores_gemma":[0.0001123606,0.002985146,0.1932083,0.00005379359,0.0002703216,0.001359832,0.0004935977,0.0007946028,0.798042,0.0004426325,0.002189517,0.00004800768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952668,0.001178723,0.001332545,0.0001252501,0.00003211006,0.00004600971,0.0014212,0.0001094739,0.0004878272],"genre_scores_gemma":[0.989637,0.001597426,0.002187317,0.0001934157,0.00002749029,0.0002176623,0.00164625,0.00005702627,0.004436573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711021,"threshold_uncertainty_score":0.005723894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0528483589171525,"score_gpt":0.3404844235437924,"score_spread":0.2876360646266399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}