{"id":"W4400600249","doi":"10.1139/bcb-2024-0018","title":"The importance of prion research","year":2024,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Sunnybrook Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Disease; Mechanism (biology); Human health; Human disease; Neuroscience; Biology; Prion protein; Translational research; Medicine; Biotechnology; Pathology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002306412,0.001034274,0.001479966,0.002602544,0.0008054866,0.002571519,0.001437077,0.003464943,0.002560191],"category_scores_gemma":[0.002421455,0.0003409503,0.0006754556,0.002079118,0.002196376,0.004490448,0.00179249,0.005588878,0.002158888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001660418,"about_ca_system_score_gemma":0.004033817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001839924,"about_ca_topic_score_gemma":0.001477358,"domain_scores_codex":[0.9991503,0.0002293479,0.00008987399,0.0001144256,0.0003332724,0.00008273124],"domain_scores_gemma":[0.9984025,0.0008566914,0.00009525949,0.00007174617,0.0004092161,0.0001646299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001122666,0.00008399545,0.0002570155,0.01812592,0.0001105032,0.0007717439,0.000492817,0.0004542473,0.003603067,0.05415973,0.1501023,0.7717265],"study_design_scores_gemma":[0.000007462471,0.00003132107,0.0002008834,0.00219468,0.00002073118,0.0007567753,0.0000702199,0.00003096606,0.0002011735,0.00696741,0.989507,0.00001151111],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005528913,0.995739,0.000107932,0.00162953,0.001316084,0.000002075397,0.000005350709,0.000005565029,0.001139232],"genre_scores_gemma":[0.0006855745,0.9950818,0.0001650471,0.001411355,0.001774519,0.000005095587,0.00001651937,0.00000284214,0.0008572906],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003464943,"threshold_uncertainty_score":0.01219761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04323530157645182,"score_gpt":0.3784100936527277,"score_spread":0.3351747920762759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}