{"id":"W4400608613","doi":"10.1101/2024.07.12.603298","title":"Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge; University of Calgary; University of Toronto; Alberta Children's Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Cell biology; Wnt signaling pathway; Biology; Glycolysis; Cellular differentiation; Progenitor cell; Signal transduction; Stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007268834,0.0002544908,0.0001299696,0.0001976147,0.0001286153,0.0004336468,0.0001254921,0.0001865521,0.0009173274],"category_scores_gemma":[0.00007890429,0.000175552,0.0001301275,0.0001433671,0.0001693442,0.0002140969,0.0002318451,0.0004048325,0.0002489464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003797017,"about_ca_system_score_gemma":0.0002004105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007704014,"about_ca_topic_score_gemma":0.001289668,"domain_scores_codex":[0.9998975,0.00001344122,0.000009325647,0.00002464215,0.00002690627,0.00002823435],"domain_scores_gemma":[0.9999275,0.000005600005,0.00003035084,0.000004622285,0.000007896867,0.00002404361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008208639,0.00000623199,0.000442208,0.00001919326,0.00000257088,0.00003016658,0.000007259454,0.00004286161,0.9984556,0.00018434,0.00002776114,0.0006996953],"study_design_scores_gemma":[0.00002551541,0.0001022016,0.01577966,0.00001301269,0.0000246995,0.0001536479,0.00004416317,0.002414514,0.9772927,0.000130701,0.004013088,0.000006156254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884782,0.002382059,0.005173654,0.0001602452,0.00002962935,0.00002378722,0.0007650246,0.0001370511,0.002850362],"genre_scores_gemma":[0.9935791,0.001185318,0.001909026,0.0000486704,0.000006386244,0.00002190882,0.0003354533,0.00002388597,0.002890103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009173274,"threshold_uncertainty_score":0.003068745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006532452971647725,"score_gpt":0.2031792194681628,"score_spread":0.1966467664965151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}