{"id":"W4400608916","doi":"10.1186/s12944-024-02203-z","title":"Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: a double-blind randomized controlled trial","year":2024,"lang":"en","type":"article","venue":"Lipids in Health and Disease","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; HEC Montréal","funders":"Shiraz University; Shiraz University of Medical Sciences; Iran National Science Foundation; National Science Foundation","keywords":"Internal medicine; Medicine; Circadian clock; CLOCK; Gastroenterology; Ulcerative colitis; Inflammatory bowel disease; Calprotectin; Circadian rhythm; Butyrate; Placebo; Colitis; Endocrinology; Immunology; Biology; Pathology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001899129,0.001781239,0.007632521,0.000623246,0.0008348559,0.00135841,0.001017396,0.002975805,0.006927814],"category_scores_gemma":[0.001961321,0.0009553555,0.002855229,0.000660372,0.001470272,0.001264981,0.0005694529,0.002685845,0.0007578026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006821313,"about_ca_system_score_gemma":0.001221078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205712,"about_ca_topic_score_gemma":0.001780145,"domain_scores_codex":[0.9991442,0.0003535311,0.000111063,0.0002047465,0.00007305614,0.0001135283],"domain_scores_gemma":[0.9987087,0.0003026482,0.0003279493,0.00009951091,0.0001477147,0.0004133331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9894832,0.003136074,0.0002528433,0.001136263,0.0008811385,0.00001568159,0.0000182641,0.00004991658,0.001092903,0.00001964843,0.0001520743,0.003761995],"study_design_scores_gemma":[0.9594813,0.03787944,0.001141125,0.00006459541,0.0008433693,0.00001004569,0.00001517355,0.0001412165,0.0001486727,0.0000401349,0.0002248971,0.00000995458],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588654,0.02632518,0.0009772136,0.001203533,0.002106065,0.008008949,0.001114127,0.0001819285,0.001217635],"genre_scores_gemma":[0.9686358,0.01012911,0.002494849,0.00180403,0.001080968,0.01174199,0.00096916,0.00003226743,0.003111877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007632521,"threshold_uncertainty_score":0.02317584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381631408182099,"score_gpt":0.3190269231193,"score_spread":0.305210609037479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}