{"id":"W4400613746","doi":"10.1016/j.crstbi.2024.100156","title":"Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system","year":2024,"lang":"en","type":"article","venue":"Current Research in Structural Biology","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; York University; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University; U.S. Department of Energy","keywords":"Plasmid; Secretion; Chaperone (clinical); Bacteria; Protein disulfide-isomerase; Isomerase; Cell biology; Biology; Chemistry; Disulfide bond; Biochemistry; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004615592,0.0001547168,0.0002328069,0.0001262479,0.0001661547,0.00002508396,0.0003856497,0.000122822,0.000007774102],"category_scores_gemma":[0.0002940511,0.00007732397,0.00006497736,0.0004333737,0.001331242,0.0000120033,0.0008034441,0.0004424301,0.00000110241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006602337,"about_ca_system_score_gemma":0.0001562041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002513475,"about_ca_topic_score_gemma":0.0002521415,"domain_scores_codex":[0.9980286,0.0007364778,0.0002524092,0.000389081,0.0002437658,0.0003496993],"domain_scores_gemma":[0.999158,0.0001725988,0.00006378248,0.0003582611,0.0001919462,0.00005537155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002570942,0.000006091829,0.006231729,0.0004519914,0.00005975302,0.000001182679,0.0005368014,0.000004697259,0.9672166,0.001925784,0.00004104602,0.0232673],"study_design_scores_gemma":[0.001663744,0.002221284,0.3478278,0.001096486,0.00004229585,0.00005632167,0.001585767,0.01171969,0.6194307,0.005008275,0.00877703,0.0005706404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816108,0.0168309,0.000003872311,0.0004189628,0.0006297355,0.0004245109,0.00003706438,0.000006222088,0.00003791102],"genre_scores_gemma":[0.997809,0.001936638,0.000009884876,0.000002619979,0.0001585666,0.00002695992,0.00003386884,0.000009633085,0.00001282788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3477859,"threshold_uncertainty_score":0.4905016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04525015666639062,"score_gpt":0.3795788193458514,"score_spread":0.3343286626794607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}