{"id":"W4400618115","doi":"10.1016/j.kint.2024.07.002","title":"Sox9 flips the switch between regeneration and fibrosis","year":2024,"lang":"en","type":"article","venue":"Kidney International","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Chinook Therapeutics","keywords":"Regeneration (biology); SOX9; Fibrosis; Medicine; Cell biology; Biology; Internal medicine; Genetics; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005398711,0.0002493117,0.0002429383,0.0003230568,0.000396244,0.001171085,0.0002562079,0.0005132305,0.006291673],"category_scores_gemma":[0.0006666559,0.0002372663,0.0002242341,0.0001276495,0.0008703069,0.0007042103,0.000762291,0.001367875,0.001493493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003757021,"about_ca_system_score_gemma":0.0004407854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004262097,"about_ca_topic_score_gemma":0.0009749123,"domain_scores_codex":[0.9995906,0.00005253214,0.00002661572,0.0000688536,0.0001554647,0.0001060177],"domain_scores_gemma":[0.9994918,0.0000901587,0.0001229686,0.0000492039,0.00009204631,0.000153792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005537001,0.00006176774,0.003205657,0.0001071651,0.00002394494,0.0004649216,0.000157629,0.0002125911,0.9413842,0.01260573,0.002921179,0.03830155],"study_design_scores_gemma":[0.0001090864,0.0004239696,0.01755356,0.00008337246,0.00003702511,0.00119852,0.0007159107,0.001690793,0.9144344,0.005082139,0.05863865,0.00003257653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9346672,0.005790344,0.01219374,0.005519656,0.002853149,0.00005002931,0.0005083854,0.0006763,0.03774121],"genre_scores_gemma":[0.9790074,0.00137104,0.001746855,0.0005318023,0.0001690957,0.00001366578,0.0001797273,0.0001050147,0.01687548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006291673,"threshold_uncertainty_score":0.02104771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523674274914986,"score_gpt":0.284487169918601,"score_spread":0.2692504271694511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}