{"id":"W4400618820","doi":"10.1016/j.vaccine.2024.07.001","title":"Meeting report: Considerations for trial design and endpoints in licensing therapeutic HPV16/18 vaccines to prevent cervical cancer","year":2024,"lang":"en","type":"article","venue":"Vaccine","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"World Health Organization; Bill and Melinda Gates Foundation","keywords":"Licensure; Medicine; Cervical cancer; HPV vaccines; Clinical trial; Vaccination; HPV infection; Cancer; Family medicine; Intensive care medicine; Immunology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4575983,0.001979999,0.003126609,0.002555435,0.002837231,0.01213862,0.005829398,0.02016869,0.02620552],"category_scores_gemma":[0.5307853,0.001693235,0.006455855,0.002936359,0.002173137,0.006513443,0.003881677,0.01573449,0.01657339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008128583,"about_ca_system_score_gemma":0.01879703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001810392,"about_ca_topic_score_gemma":0.003208703,"domain_scores_codex":[0.5394394,0.3914563,0.02921184,0.005190365,0.03151331,0.003188635],"domain_scores_gemma":[0.4502452,0.3799988,0.02732837,0.02302589,0.108411,0.01099075],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004932204,0.0002188078,0.0008295853,0.006951023,0.0007458756,0.0002892879,0.0006623462,0.001487104,0.000928956,0.01691709,0.6965212,0.2695165],"study_design_scores_gemma":[0.003539371,0.001582035,0.002919827,0.01425517,0.000847667,0.0004316432,0.0004474843,0.002727735,0.001277683,0.04303358,0.9287062,0.000231608],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.002763814,0.04031633,0.08013326,0.6707042,0.09477265,0.03904355,0.006696987,0.001274705,0.06429454],"genre_scores_gemma":[0.03468595,0.02451849,0.2406046,0.4333258,0.07131258,0.1630415,0.003827318,0.00139814,0.02728571],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.5424017,"threshold_uncertainty_score":0.668878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1170485133730274,"score_gpt":0.4175162977369552,"score_spread":0.3004677843639278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}