{"id":"W4400624306","doi":"10.1016/j.jaip.2024.07.002","title":"Interleukin (IL)-1/IL-6-Inhibitor–Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses","year":2024,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Janeway Children's Health and Rehabilitation Centre; University of Victoria; Hospital for Sick Children; University of British Columbia; ASTER; London Health Sciences Centre","funders":"Lucile Packard Foundation for Children's Health; National Institute of General Medical Sciences; National Institutes of Health; Swedish Orphan Biovitrum; Fonds Wetenschappelijk Onderzoek; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Childhood Arthritis and Rheumatology Research Alliance; Rheumatology Research Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Biogen; Vlaamse regering; Pfizer; Amgen; Arthritis Foundation; Eli Lilly and Company; David and Lucile Packard Foundation","keywords":"Medicine; Systemic inflammation; Systemic disease; Eosinophilia; Immunology; Interleukin; Disease; Drug; Pulmonary Eosinophilia; Immunopathology; Inflammation; Internal medicine; Pharmacology; Cytokine; Eosinophil; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008213111,0.000459432,0.0005130703,0.0009505439,0.0003286316,0.0006602866,0.0002430196,0.000842931,0.001687304],"category_scores_gemma":[0.002159394,0.0001775558,0.0003710499,0.0005174611,0.00049459,0.0006593277,0.0005019933,0.001063712,0.0004202973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001385379,"about_ca_system_score_gemma":0.0002689389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373257,"about_ca_topic_score_gemma":0.000500535,"domain_scores_codex":[0.9992435,0.0003058297,0.0001545994,0.00006015657,0.0001046117,0.0001313719],"domain_scores_gemma":[0.9987389,0.0004248673,0.0004599235,0.00004580022,0.00009922469,0.0002313015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002050517,0.0004318677,0.788525,0.0007479604,0.0001659773,0.1270886,0.0003949295,0.0002839012,0.008089174,0.00157954,0.003277279,0.06736526],"study_design_scores_gemma":[0.0001301655,0.0009603535,0.622092,0.0004341135,0.0002268245,0.3597487,0.0008578022,0.001670818,0.002134421,0.000988601,0.01072182,0.0000344472],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9384688,0.03602565,0.002189343,0.001904625,0.000477173,0.0000891813,0.0001145346,0.00006333987,0.02066758],"genre_scores_gemma":[0.9932412,0.004208606,0.0008320049,0.0003874706,0.0005552013,0.00001515086,0.00007885227,0.000004455139,0.0006769844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001687304,"threshold_uncertainty_score":0.005644619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390210432668284,"score_gpt":0.3204136131737288,"score_spread":0.306511508847046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}