{"id":"W4400624306","doi":"10.1016/j.jaip.2024.07.002","title":"Interleukin (IL)-1/IL-6-Inhibitor–Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses","year":2024,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Janeway Children's Health and Rehabilitation Centre; University of Victoria; Hospital for Sick Children; University of British Columbia; ASTER; London Health Sciences Centre","funders":"Lucile Packard Foundation for Children's Health; National Institute of General Medical Sciences; National Institutes of Health; Swedish Orphan Biovitrum; Fonds Wetenschappelijk Onderzoek; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Childhood Arthritis and Rheumatology Research Alliance; Rheumatology Research Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Biogen; Vlaamse regering; Pfizer; Amgen; Arthritis Foundation; Eli Lilly and Company; David and Lucile Packard Foundation","keywords":"Medicine; Systemic inflammation; Systemic disease; Eosinophilia; Immunology; Interleukin; Disease; Drug; Pulmonary Eosinophilia; Immunopathology; Inflammation; Internal medicine; Pharmacology; Cytokine; Eosinophil; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.005198219,0.0002025791,0.0006833826,0.0003306663,0.00009376855,0.00005268685,0.0001882393,0.0003239384,0.000011866],"category_scores_gemma":[0.002010595,0.0001264843,0.00007882831,0.0003214282,0.0005215813,0.0007372092,0.0001126571,0.002368809,0.00001299041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650028,"about_ca_system_score_gemma":0.0004571893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001221841,"about_ca_topic_score_gemma":0.0001559718,"domain_scores_codex":[0.9959841,0.001606069,0.001588415,0.0002264817,0.0003027133,0.0002922409],"domain_scores_gemma":[0.9958157,0.002888939,0.0006987884,0.0002534993,0.000270062,0.00007304132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1669531,0.009185752,0.2740301,0.004411925,0.09159224,0.03173146,0.07619384,0.0004369433,0.1583773,0.0112955,0.006318135,0.1694736],"study_design_scores_gemma":[0.03517096,0.01517817,0.6052202,0.04784236,0.005420792,0.105084,0.1506473,0.002381525,0.00126591,0.0009881331,0.02924709,0.001553523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639734,0.03163923,0.000009250354,0.003117285,0.0006272233,0.0002746577,0.000001230993,0.00002447718,0.0003332376],"genre_scores_gemma":[0.9384128,0.06103924,0.00001006153,0.0001443639,0.0001073396,0.000008184186,0.000002179373,0.00002530661,0.0002505126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3311901,"threshold_uncertainty_score":0.9999328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390210432668284,"score_gpt":0.3204136131737288,"score_spread":0.306511508847046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}