{"id":"W4400641762","doi":"10.3390/biomedicines12071569","title":"Carnosic Acid (CA) Induces a Brown Fat-like Phenotype, Increases Mitochondrial Biogenesis, and Activates AMPK in 3T3-L1 Adipocytes","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children","keywords":"AMPK; PRDM16; Mitochondrial biogenesis; White adipose tissue; Endocrinology; Adipose tissue; Internal medicine; Adipocyte; Chemistry; Brown adipose tissue; Thermogenesis; 3T3-L1; mTORC1; Thermogenin; Biology; Cell biology; Protein kinase A; Mitochondrion; Signal transduction; Phosphorylation; PI3K/AKT/mTOR pathway; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001440336,0.0003666466,0.0006655431,0.0007887498,0.00007691549,0.00005503602,0.0001269746,0.0002315336,0.000209323],"category_scores_gemma":[0.0002371344,0.0002668137,0.00009284088,0.0009773073,0.0003445575,0.0002144232,0.00008360976,0.0002319542,0.00006801639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004864981,"about_ca_system_score_gemma":0.0001787394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002163632,"about_ca_topic_score_gemma":0.0001807206,"domain_scores_codex":[0.9981135,0.00006535347,0.0004157607,0.000593328,0.0003664441,0.0004456268],"domain_scores_gemma":[0.9990292,0.000209741,0.00006526505,0.0003102456,0.00007531996,0.000310249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000353612,0.0001882066,0.00652571,0.0004848305,0.0002757712,0.0003617747,0.0009426342,7.831799e-8,0.9314927,0.0001764849,0.01649327,0.04270495],"study_design_scores_gemma":[0.005428145,0.0009948881,0.1119204,0.002772591,0.001531173,0.000469826,0.001282403,0.00006595629,0.3285314,0.0005831559,0.5455498,0.0008702128],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8730577,0.1228017,0.00001221413,0.001516285,0.001491404,0.0004821025,0.00005152098,0.0001802611,0.0004068591],"genre_scores_gemma":[0.9909913,0.003216539,0.0004689609,0.0005460405,0.003341508,0.00007322651,0.0001478341,0.00006138116,0.00115324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6029612,"threshold_uncertainty_score":0.9999784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820258066058871,"score_gpt":0.2781709118660247,"score_spread":0.2599683312054359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}