{"id":"W4400641762","doi":"10.3390/biomedicines12071569","title":"Carnosic Acid (CA) Induces a Brown Fat-like Phenotype, Increases Mitochondrial Biogenesis, and Activates AMPK in 3T3-L1 Adipocytes","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children","keywords":"AMPK; PRDM16; Mitochondrial biogenesis; White adipose tissue; Endocrinology; Adipose tissue; Internal medicine; Adipocyte; Chemistry; Brown adipose tissue; Thermogenesis; 3T3-L1; mTORC1; Thermogenin; Biology; Cell biology; Protein kinase A; Mitochondrion; Signal transduction; Phosphorylation; PI3K/AKT/mTOR pathway; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203663,0.0005680315,0.0005913345,0.0005042895,0.0003669768,0.0003096177,0.0003082714,0.0004746375,0.001564931],"category_scores_gemma":[0.0001045313,0.0003183939,0.0008669011,0.0004771343,0.0003766603,0.0002719401,0.0002820677,0.001116137,0.0003200138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005896259,"about_ca_system_score_gemma":0.0005051341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002956879,"about_ca_topic_score_gemma":0.004697949,"domain_scores_codex":[0.9997558,0.00003345487,0.00003434209,0.00006269594,0.00005125997,0.00006249084],"domain_scores_gemma":[0.9998913,0.00001405219,0.00003328937,0.00001354628,0.00001541115,0.00003252505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000769956,0.00008259084,0.0001430938,0.00008894331,0.00002046295,0.0001065391,0.00003029135,0.00004260699,0.9978637,0.0001001665,0.00008303017,0.0006685773],"study_design_scores_gemma":[0.000205021,0.001584699,0.008508453,0.00002253108,0.00008088651,0.0004212657,0.000110778,0.0006783284,0.9830404,0.0001360489,0.005189279,0.00002219552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847973,0.00813105,0.002323414,0.0005663231,0.0001860988,0.00007191838,0.001430315,0.0001833828,0.002310172],"genre_scores_gemma":[0.9910479,0.002680901,0.002012223,0.0003356251,0.00002882315,0.0001146821,0.001103419,0.00003946923,0.002636936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002956879,"threshold_uncertainty_score":0.005879283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820258066058871,"score_gpt":0.2781709118660247,"score_spread":0.2599683312054359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}