{"id":"W4400643063","doi":"10.3390/biom14070850","title":"Hepatic Gene Expression and Metabolite Profiles of Androstenone and Skatole Relative to Plasma Estrone Sulfate Levels in Boars","year":2024,"lang":"en","type":"article","venue":"Biomolecules","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund","keywords":"Androstenone; Estrone sulfate; Estrone; Metabolite; Skatole; Internal medicine; Endocrinology; Chemistry; Biology; Estrogen; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003722937,0.0002267641,0.0003488626,0.0002837942,0.00006984098,0.00002945123,0.0001082286,0.0001659241,0.00005781848],"category_scores_gemma":[0.00004457126,0.0001992177,0.0000440622,0.0003169493,0.0002463435,0.0001138661,0.0001741401,0.0002571339,0.0000125094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001464483,"about_ca_system_score_gemma":0.00005473804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002769946,"about_ca_topic_score_gemma":0.000008827443,"domain_scores_codex":[0.9985025,0.0002652692,0.0003692493,0.0004070035,0.0001323212,0.0003236627],"domain_scores_gemma":[0.9993442,0.0001944019,0.00006691079,0.0001196367,0.00004368367,0.0002311722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435036,0.00008675885,0.0028144,0.0001253018,0.00009017282,0.00007667214,0.001387559,0.00004544551,0.9794807,0.001298865,0.0001769998,0.01427366],"study_design_scores_gemma":[0.001201223,0.0000816384,0.01041839,0.00008931005,0.0001473404,0.00002924644,0.00009526747,0.003057638,0.9696729,0.0007256897,0.01424636,0.0002350086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699678,0.02761955,0.0003383536,0.0005235448,0.0003157574,0.0004504487,0.0004007021,0.00003623477,0.0003475426],"genre_scores_gemma":[0.9940423,0.001560265,0.003733916,0.0001891944,0.00005787554,0.00005610909,0.00001749113,0.00002744101,0.0003153499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02605928,"threshold_uncertainty_score":0.8123862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06719651469228174,"score_gpt":0.3978443840954117,"score_spread":0.33064786940313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}