{"id":"W4400647814","doi":"10.1016/j.jad.2024.07.029","title":"Altered oxidative neurometabolic response to methylene blue in bipolar disorder revealed by quantitative neuroimaging","year":2024,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Maudsley Biomedical Research Centre; King's College London; National Institute for Health and Care Research; Canadian Institute of Steel Construction; National Alliance for Research on Schizophrenia and Depression","keywords":"Bipolar disorder; Neuroimaging; Pathophysiology; Methylene blue; Medicine; Hemodynamics; Cardiology; Internal medicine; Mood; Magnetic resonance imaging; Neuroscience; Psychology; Psychiatry; Chemistry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004002341,0.000256521,0.0002435292,0.0002264488,0.0001225861,0.0001406039,0.00007856343,0.000217131,0.001127087],"category_scores_gemma":[0.0003692009,0.0002435738,0.0001147815,0.00008285446,0.0002711668,0.00008746321,0.0001321324,0.0001642378,0.0001016474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457334,"about_ca_system_score_gemma":0.00007632408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009139177,"about_ca_topic_score_gemma":0.00180724,"domain_scores_codex":[0.9999062,0.00003034861,0.000009289539,0.00002032077,0.00001834698,0.00001543064],"domain_scores_gemma":[0.999885,0.0000203142,0.00004166653,0.00001503663,0.0000135929,0.00002433194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02585687,0.00140035,0.1358504,0.0002115102,0.0002374457,0.0003359249,0.0004462677,0.0005127699,0.8085151,0.0000951062,0.0002083032,0.02633007],"study_design_scores_gemma":[0.000594634,0.01014875,0.9745671,0.00001744067,0.0001569038,0.0006958678,0.000131773,0.001056294,0.01216805,0.0001297959,0.0003221589,0.0000111689],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992487,0.0001591438,0.000330047,0.00001040708,0.000002716516,0.00003028801,0.00003628403,0.000004158947,0.0001781778],"genre_scores_gemma":[0.9991529,0.00009002487,0.0004910203,0.00003018833,0.00000477047,0.00003596003,0.00005859829,0.000002007055,0.0001345932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127087,"threshold_uncertainty_score":0.00377053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120474406039198,"score_gpt":0.3132806486493081,"score_spread":0.3012332080453883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}