{"id":"W4400676936","doi":"10.3390/antib13030057","title":"Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework","year":2024,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; Canada Research Chairs; National Institutes of Health; Hospital for Sick Children; Office of Science; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Paratope; Monoclonal antibody; Antibody; Antigen; Immunogenicity; Complementarity determining region; Human leukocyte antigen; Major histocompatibility complex; Computational biology; Biology; Humanized antibody; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705168,0.0002802195,0.0001157673,0.00008531689,0.00006960821,0.0001426451,0.0001828111,0.0002330612,0.00103612],"category_scores_gemma":[0.00008262895,0.00009574046,0.0001516157,0.00006142104,0.000187229,0.0001208271,0.0001542215,0.0003710167,0.0002386306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002346288,"about_ca_system_score_gemma":0.0002249165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004149167,"about_ca_topic_score_gemma":0.0006650824,"domain_scores_codex":[0.9999187,0.00001653585,0.000004450947,0.00001847697,0.00002039996,0.00002150297],"domain_scores_gemma":[0.9999549,0.000006648489,0.00001602898,0.000006050678,0.000005565546,0.00001077692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002036879,0.00001739796,0.0000817566,0.00001542768,0.000002394681,0.00003623823,0.000007679096,0.0001693203,0.9976313,0.0001874439,0.00003997584,0.001790754],"study_design_scores_gemma":[0.00001659319,0.0004760108,0.001006506,0.000005701892,0.00001138476,0.0004063654,0.00001177696,0.0008531401,0.98891,0.00004782124,0.008250344,0.000004273392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731347,0.0009235511,0.02189914,0.0001733201,0.00004517579,0.0001056011,0.0001547692,0.0001197378,0.003443996],"genre_scores_gemma":[0.9767964,0.0007108292,0.01928327,0.0001595912,0.00001070435,0.00004096786,0.0002312018,0.0000252369,0.00274168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103612,"threshold_uncertainty_score":0.003466129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04654255567493678,"score_gpt":0.4254096671673216,"score_spread":0.3788671114923849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}