{"id":"W4400676993","doi":"10.3390/cells13141201","title":"The EphA2 Receptor Regulates Invasiveness and Drug Sensitivity in Canine and Human Osteosarcoma Cells","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; Saskatchewan Health; University of Saskatchewan","funders":"National Cancer Institute; Saskatchewan Health Research Foundation; Companion Animal Health Fund; Bentham-Moxon Trust; Colorado State University; University of Wisconsin-Madison","keywords":"Osteosarcoma; EPH receptor A2; Cancer research; Gene silencing; Medicine; Metastasis; MAPK/ERK pathway; Cisplatin; Cancer; Biology; Chemotherapy; Bioinformatics; Signal transduction; Oncology; Receptor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041574,0.00014481,0.0002385874,0.0002381161,0.0001914517,0.0002655613,0.00009081591,0.0002497285,0.001088986],"category_scores_gemma":[0.0001603974,0.0001297667,0.0002662039,0.0002055581,0.0002013729,0.0002048002,0.0001678162,0.0002832224,0.0002140149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993636,"about_ca_system_score_gemma":0.0002140565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001424812,"about_ca_topic_score_gemma":0.002161432,"domain_scores_codex":[0.9997962,0.00003232826,0.00001877544,0.00003979448,0.0000721472,0.00004073892],"domain_scores_gemma":[0.9999322,0.00001395382,0.0000169785,0.000007989731,0.00001496187,0.00001390843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606375,0.0001052464,0.003083299,0.00009052559,0.00001895342,0.0001357,0.00009493879,0.0002133071,0.9928895,0.0003229254,0.0001951072,0.002589909],"study_design_scores_gemma":[0.00005320529,0.00130918,0.07387699,0.00002114906,0.0001145542,0.002532928,0.0004816327,0.004668781,0.8980087,0.0002412235,0.01866338,0.00002824311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954348,0.002019977,0.0009908576,0.00006694558,0.00001693178,0.00001662139,0.0002200563,0.00001803012,0.00121568],"genre_scores_gemma":[0.9963265,0.001044355,0.0007835529,0.00003638359,0.000005700215,0.00002602324,0.0004844432,0.000005430548,0.001287565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424812,"threshold_uncertainty_score":0.003642976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776237031498971,"score_gpt":0.2466779324759348,"score_spread":0.2289155621609451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}