{"id":"W4400676993","doi":"10.3390/cells13141201","title":"The EphA2 Receptor Regulates Invasiveness and Drug Sensitivity in Canine and Human Osteosarcoma Cells","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; Saskatchewan Health; University of Saskatchewan","funders":"National Cancer Institute; Saskatchewan Health Research Foundation; Companion Animal Health Fund; Bentham-Moxon Trust; Colorado State University; University of Wisconsin-Madison","keywords":"Osteosarcoma; EPH receptor A2; Cancer research; Gene silencing; Medicine; Metastasis; MAPK/ERK pathway; Cisplatin; Cancer; Biology; Chemotherapy; Bioinformatics; Signal transduction; Oncology; Receptor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004091715,0.0001322081,0.0001334071,0.00005028588,0.0002515878,0.0001658572,0.00008732442,0.00003643922,0.00001585509],"category_scores_gemma":[0.00003789407,0.00009800519,0.00002475149,0.0001887913,0.0002213803,0.0001365224,0.0001195552,0.000188055,0.00002690338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002105231,"about_ca_system_score_gemma":0.00002654729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001336589,"about_ca_topic_score_gemma":0.0002509802,"domain_scores_codex":[0.9988424,0.000197536,0.0001663004,0.0004071918,0.0001401292,0.0002464137],"domain_scores_gemma":[0.9987208,0.001023081,0.00003358458,0.0001440282,0.00001112555,0.00006742845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001065749,0.00001004289,0.0003170265,0.00004226405,0.000001357833,0.0001363706,0.0003118241,0.00001492165,0.9963142,0.0006453336,0.0006019666,0.001594083],"study_design_scores_gemma":[0.0001262702,0.00002843407,0.0009714904,0.00009574591,0.000004518321,0.00002032163,0.00006803853,0.0002577142,0.9905036,0.0004147872,0.007388878,0.0001201818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977713,0.0008265849,0.000003842566,0.0005750263,0.0003155962,0.0001766116,0.00001103699,0.00004278735,0.0002772029],"genre_scores_gemma":[0.9978784,0.0004165869,0.00001106662,0.0002623173,0.00007661692,0.000005906512,7.226682e-7,0.00001865457,0.001329725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006786911,"threshold_uncertainty_score":0.3996536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776237031498971,"score_gpt":0.2466779324759348,"score_spread":0.2289155621609451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}