{"id":"W4400680680","doi":"10.1016/j.isci.2024.110529","title":"Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Oesterreichische Nationalbank; Österreichischen Akademie der Wissenschaften; Rosetrees Trust; European Commission; National Institute for Health and Care Research; Universität Innsbruck; Austrian Science Fund; University College London; Cancer Research UK; Wellcome Trust","keywords":"Tumor microenvironment; Immunotherapy; Immune system; Evasion (ethics); Computational biology; Biology; Cancer immunotherapy; Immune escape; Tumor heterogeneity; Cancer; Cancer research; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922933,0.0002550251,0.0003626051,0.000441799,0.0001484786,0.0004783187,0.0001365815,0.0003014875,0.0007370706],"category_scores_gemma":[0.000203602,0.0001497823,0.0001974185,0.0003657617,0.00040073,0.0004433011,0.0002715168,0.0004284796,0.0001864064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002324906,"about_ca_system_score_gemma":0.000182348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003837245,"about_ca_topic_score_gemma":0.0007504974,"domain_scores_codex":[0.9998968,0.00001126454,0.000004499566,0.00004101282,0.00002728788,0.00001910754],"domain_scores_gemma":[0.9999015,0.00003296966,0.00002682849,0.00001320081,0.00001447638,0.00001103756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004311119,0.000007316432,0.002403079,0.00005184346,0.00001120984,0.00003690616,0.00002815655,0.0009632502,0.9924284,0.0002403249,0.00003929098,0.003747241],"study_design_scores_gemma":[0.00001171745,0.0002374663,0.1139847,0.00002523861,0.0001002056,0.0005034564,0.000490564,0.05914595,0.8178575,0.004031328,0.003566139,0.00004578751],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9334518,0.001256005,0.06163817,0.0001546083,0.00002251058,0.00002818066,0.001524311,0.0002348345,0.001689689],"genre_scores_gemma":[0.9859763,0.0006509298,0.01203648,0.00006501299,0.00001551234,0.00002903742,0.0005897828,0.00004166374,0.0005951893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007370706,"threshold_uncertainty_score":0.002465725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251971421848677,"score_gpt":0.2529188994732081,"score_spread":0.2403991852547213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}