{"id":"W4400683471","doi":"10.22541/au.172114395.55022246/v1","title":"RNAi Library Screening Reveals Gβ1, Casein Kinase 2α and ICAP-1 as Novel Regulators of LFA-1-mediated T-cell Polarity and Migration","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"RNA interference; Cell biology; Casein kinase 2; Chemistry; Polarity (international relations); Kinase; Protein kinase A; Biology; Cell; Gene; Biochemistry; Mitogen-activated protein kinase kinase; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229664,0.0007087097,0.0004603061,0.0005298821,0.0002447141,0.0004383424,0.0003244955,0.0003253521,0.001024502],"category_scores_gemma":[0.0001149287,0.0002214449,0.0003960176,0.0003987858,0.0002488583,0.0001242368,0.0001763316,0.0005318464,0.0005956965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005495457,"about_ca_system_score_gemma":0.0003536519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133579,"about_ca_topic_score_gemma":0.002213739,"domain_scores_codex":[0.9998463,0.00001128141,0.00001397545,0.00003523943,0.00006165703,0.0000315896],"domain_scores_gemma":[0.999903,0.00001963004,0.00003496074,0.000008886922,0.00001234786,0.00002122915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003727051,0.00001016084,0.0001145183,0.00002455901,0.000005692553,0.00005732155,0.000005678704,0.0001328183,0.9986443,0.00005379174,0.0000519988,0.0008619037],"study_design_scores_gemma":[0.00002415723,0.0001260873,0.005728914,0.000008354042,0.00008457763,0.0002874428,0.00002626853,0.002656496,0.9859334,0.00004628941,0.00506852,0.000009475556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763252,0.002059768,0.01228665,0.0002267209,0.00005511109,0.0001447977,0.003917434,0.0005445176,0.004439846],"genre_scores_gemma":[0.9674339,0.002618538,0.01269714,0.0002283061,0.00002014217,0.0001846923,0.007311639,0.0001813397,0.009324226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133579,"threshold_uncertainty_score":0.003987193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239463436152674,"score_gpt":0.2922520029078972,"score_spread":0.2683056592926298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}