{"id":"W4400689563","doi":"10.1242/dev.202798","title":"FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton","year":2024,"lang":"en","type":"article","venue":"Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; National Institutes of Health; University of Alberta; National Heart, Lung, and Blood Institute; Ministry of Health – Kingdom of Saudi Arabia; Women and Children's Health Research Institute","keywords":"Endochondral ossification; Chondrocyte; Biology; Indian hedgehog; Ossification center; Cartilage; Anatomy; Osteoblast; Ossification; Chondrogenesis; Cell biology; Progenitor cell; Endocrinology; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753131,0.000343859,0.0001726362,0.0005091259,0.0002421546,0.0002936247,0.0002152753,0.0003841892,0.001223466],"category_scores_gemma":[0.00009696901,0.0003102305,0.0002040702,0.0001710268,0.0003767691,0.0001874847,0.0002493207,0.000488307,0.0004220444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005246921,"about_ca_system_score_gemma":0.0004669242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002455427,"about_ca_topic_score_gemma":0.004078039,"domain_scores_codex":[0.9998266,0.00001514225,0.000008820892,0.0000382184,0.00005803595,0.0000531767],"domain_scores_gemma":[0.9998769,0.00001044272,0.00003038357,0.00000865182,0.00001569068,0.00005791778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008838739,0.00001100828,0.0003367951,0.00001435147,0.000001755717,0.00005534645,0.00001969531,0.00004603143,0.9982668,0.000213218,0.00005428424,0.0008921414],"study_design_scores_gemma":[0.00004001883,0.0001398166,0.02174699,0.00001396849,0.00001629046,0.000371086,0.0000575941,0.0009981908,0.9710136,0.0001320899,0.005461394,0.000008903872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862596,0.003540844,0.005165085,0.0002011232,0.00003644774,0.00003400191,0.0007565004,0.0001683118,0.003838173],"genre_scores_gemma":[0.9770258,0.00178069,0.003980182,0.0001335716,0.00001377181,0.00008672319,0.0005124274,0.00008285839,0.01638394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002455427,"threshold_uncertainty_score":0.004882216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008006766814813876,"score_gpt":0.2268224595137588,"score_spread":0.218815692698945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}