{"id":"W4400692075","doi":"10.1093/eurheartj/ehae409","title":"A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers","year":2024,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Fonds de Recherche du Québec - Santé; Schweizerische Herzstiftung; Medical Research Council Canada; NIHR Imperial Biomedical Research Centre; ZonMw; National Science Foundation; Imperial College London; Hartstichting; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Rosetrees Trust; Baugarten Stiftung; Sir Jules Thorn Charitable Trust; Georg und Bertha Schwyzer-Winiker-Stiftung; British Heart Foundation; National Institute for Health and Care Research","keywords":"Medicine; Internal medicine; Hazard ratio; Desmoplakin; Interquartile range; Cardiology; Cardiomyopathy; Cohort; Population; Ventricular tachycardia; Confidence interval; Heart failure; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003044607,0.0001505945,0.000285506,0.0002555173,0.0001068201,0.0001696816,0.000069596,0.00004215974,0.00003963816],"category_scores_gemma":[0.0004618431,0.000131537,0.0003990172,0.0002188895,0.00003237294,0.0001477911,0.00002033798,0.000573751,0.00009972641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567909,"about_ca_system_score_gemma":0.0002114311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001086355,"about_ca_topic_score_gemma":0.00000416456,"domain_scores_codex":[0.9985693,0.0002353677,0.0003551892,0.0002829884,0.0002754788,0.0002816598],"domain_scores_gemma":[0.9992606,0.0001367401,0.00005564113,0.0003032748,0.00007608708,0.0001676748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002519844,0.0005067484,0.01151647,0.001042886,0.00187376,0.02349767,0.00340718,0.005039173,0.7236972,0.0008246871,0.03726967,0.1888047],"study_design_scores_gemma":[0.01159221,0.001379438,0.6533334,0.002867696,0.00150744,0.1171282,0.0002327398,0.02027192,0.01093668,0.0003424738,0.1794117,0.0009961177],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.914583,0.003012841,0.07842399,0.0009094584,0.001013034,0.0009831401,0.00004433327,0.00008995328,0.0009402613],"genre_scores_gemma":[0.9812621,0.00017922,0.01656072,0.0001382857,0.001526281,0.00001489493,0.0000165289,0.0000783562,0.0002235528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7127605,"threshold_uncertainty_score":0.5363923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02464771033701592,"score_gpt":0.290901252284759,"score_spread":0.2662535419477431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}