{"id":"W4400722773","doi":"10.3390/ijms25147828","title":"Vascular Endothelial Growth Factor C (VEGF-C) Sensitizes Lymphatic Endothelial Cells to Oxidative-Stress-Induced Apoptosis through DNA Damage and Mitochondrial Dysfunction: Implications for Lymphedema","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"University Hospital Foundation","keywords":"Oxidative stress; Lymphatic system; Lymphangiogenesis; Vascular endothelial growth factor; Lymphatic Endothelium; Lymphedema; Vascular endothelial growth factor C; DNA damage; Reactive oxygen species; Pathology; Medicine; Vascular endothelial growth factor A; Biology; Immunology; Cancer research; Cell biology; Endocrinology; Internal medicine; Cancer; Biochemistry; Metastasis; VEGF receptors; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788103,0.000350483,0.000272621,0.0003154399,0.0002000797,0.0003274448,0.0002018729,0.0004843211,0.0009634537],"category_scores_gemma":[0.0002203612,0.00009348567,0.0003714295,0.0002022293,0.0003217205,0.0003460607,0.0002060147,0.0006648336,0.0001039394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003833526,"about_ca_system_score_gemma":0.0002326666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769279,"about_ca_topic_score_gemma":0.0004396575,"domain_scores_codex":[0.9998307,0.0000443761,0.0000178358,0.00002983916,0.00003342061,0.00004383259],"domain_scores_gemma":[0.9998317,0.0000215685,0.00006521433,0.00001106846,0.00003319615,0.00003717591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007450703,0.0003535842,0.003622496,0.0006789353,0.00006017537,0.0007713173,0.0000835352,0.0002211872,0.9728125,0.0007899098,0.0005818514,0.01927936],"study_design_scores_gemma":[0.000226605,0.004087801,0.08138251,0.0001732331,0.0002034205,0.004628072,0.0002975743,0.003069436,0.8843852,0.001635425,0.01986496,0.00004581374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9119812,0.07448684,0.007287458,0.002820681,0.000482021,0.0001110155,0.0003199483,0.0001225064,0.002388281],"genre_scores_gemma":[0.9843933,0.01266988,0.001199717,0.0004129536,0.00006631378,0.0000412408,0.0001086254,0.000004793613,0.001103172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009634537,"threshold_uncertainty_score":0.003223062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655130308980598,"score_gpt":0.3098467134643032,"score_spread":0.2832954103744972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}