{"id":"W4400722773","doi":"10.3390/ijms25147828","title":"Vascular Endothelial Growth Factor C (VEGF-C) Sensitizes Lymphatic Endothelial Cells to Oxidative-Stress-Induced Apoptosis through DNA Damage and Mitochondrial Dysfunction: Implications for Lymphedema","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"University Hospital Foundation","keywords":"Oxidative stress; Lymphatic system; Lymphangiogenesis; Vascular endothelial growth factor; Lymphatic Endothelium; Lymphedema; Vascular endothelial growth factor C; DNA damage; Reactive oxygen species; Pathology; Medicine; Vascular endothelial growth factor A; Biology; Immunology; Cancer research; Cell biology; Endocrinology; Internal medicine; Cancer; Biochemistry; Metastasis; VEGF receptors; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002516379,0.0002096819,0.0003354998,0.0003548708,0.0001421404,0.0003687316,0.0003424478,0.00006651296,0.0000431064],"category_scores_gemma":[0.0005225535,0.0001586829,0.0003291628,0.000275507,0.0001550915,0.0004411265,0.00006759601,0.00002266925,0.00001209121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161147,"about_ca_system_score_gemma":0.0006353568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004236218,"about_ca_topic_score_gemma":0.000002749769,"domain_scores_codex":[0.9978692,0.00008439008,0.0005505213,0.0003786647,0.0008836463,0.0002335742],"domain_scores_gemma":[0.998292,0.0004416543,0.0002028093,0.0001451741,0.0006833057,0.0002350982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001916236,0.0001358036,0.0005136292,0.00009291939,0.0005339244,0.00008451305,0.0008007359,0.00003409905,0.9908485,0.003721939,0.00037278,0.002669536],"study_design_scores_gemma":[0.003285995,0.0008525117,0.002059443,0.0008145442,0.0004339554,0.0006146589,0.0008158879,0.0003284244,0.9855184,0.003178426,0.001809804,0.0002879431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954201,0.0005823509,0.03550969,0.005342758,0.003109863,0.0005128548,0.0003417751,0.00003568438,0.0003640681],"genre_scores_gemma":[0.9909329,0.00008603241,0.006679893,0.0009260661,0.00126188,0.00003299964,0.000009863612,0.00001890169,0.0000514288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03673198,"threshold_uncertainty_score":0.6470899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655130308980598,"score_gpt":0.3098467134643032,"score_spread":0.2832954103744972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}