{"id":"W4400724181","doi":"10.3390/antib13030059","title":"Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database","year":2024,"lang":"en","type":"article","venue":"Antibodies","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Adverse effect; CTLA-4; PD-L1; Immune system; Database; Medicine; Immunology; Computer science; Pharmacology; Immunotherapy; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004657594,0.0002016925,0.0005148149,0.0003254963,0.00007485858,0.000003532339,0.0001501583,0.00007865413,0.0002063422],"category_scores_gemma":[0.00005666799,0.0001348175,0.0004764081,0.000812724,0.000253875,0.0002268594,0.0001392265,0.0001407646,0.000005623265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004984985,"about_ca_system_score_gemma":0.0001039144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00147873,"about_ca_topic_score_gemma":0.0002450619,"domain_scores_codex":[0.9984521,0.00007933801,0.000579405,0.0003178247,0.0003673812,0.0002039705],"domain_scores_gemma":[0.9989812,0.00005867771,0.0001909826,0.0006165231,0.00009014466,0.00006250145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002231583,0.0005646042,0.3091535,0.001291622,0.007604946,0.00004475808,0.00403701,0.00003149054,0.6689032,0.00007502849,0.000382166,0.005680038],"study_design_scores_gemma":[0.001969447,0.0003149792,0.8296615,0.00185945,0.003704321,0.00001990482,0.002639652,0.001042802,0.1561396,0.00004577947,0.002344395,0.0002581934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946833,0.003775004,0.00001521221,0.0003602633,0.0003881706,0.0002873819,0.0001963007,0.00003211618,0.0002622512],"genre_scores_gemma":[0.9967879,0.002023115,0.0001263327,0.00008674987,0.00006671172,0.000006226474,0.0001438975,0.00002037347,0.0007387093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5205079,"threshold_uncertainty_score":0.5497697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497849639980328,"score_gpt":0.2970432694413767,"score_spread":0.2820647730415734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}