{"id":"W4400728053","doi":"10.1038/s41420-024-02097-x","title":"Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies","year":2024,"lang":"en","type":"review","venue":"Cell Death Discovery","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Hubei University; Hubei University of Technology; National Natural Science Foundation of China; University of Alberta","keywords":"Transfer RNA; Methylation; Translation (biology); Methyltransferase; Reprogramming; Biology; Autophagy; Cancer research; Cancer; RNA; RNA methylation; Epigenetics; Protein biosynthesis; microRNA; Computational biology; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447867,0.0002003601,0.000386978,0.00009127938,0.00002434922,0.00006948043,0.00009357549,0.0002057073,0.000005691586],"category_scores_gemma":[0.000003779995,0.000159604,0.000132414,0.0001214424,0.00002711493,0.00001471092,0.00004591925,0.0001031078,0.000001222673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003567536,"about_ca_system_score_gemma":0.0002764419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005638541,"about_ca_topic_score_gemma":0.00002224846,"domain_scores_codex":[0.9990577,0.00006783279,0.0003357473,0.0003358151,0.00008167092,0.0001212526],"domain_scores_gemma":[0.9996033,0.00001134966,0.0001828693,0.0001603905,0.00002285741,0.00001920207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002349493,0.00009254378,0.00002288117,0.02189087,0.0002602829,0.000002885034,0.0001302424,0.0004951588,0.08764829,0.0134636,0.0001601505,0.8758096],"study_design_scores_gemma":[0.0006633414,0.0003406634,0.0002916561,0.009300641,0.002680659,0.000009263141,0.0006284239,0.0005909647,0.01796652,0.0114935,0.9544946,0.00153978],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001479351,0.9940709,0.003611933,0.000006421112,0.0001327418,0.0002851799,0.00005889227,0.000004745937,0.0003498002],"genre_scores_gemma":[0.04242055,0.9563798,0.0001538233,0.00000642843,0.00008576564,0.0001057681,0.0002573235,0.00003205253,0.0005585104],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9543344,"threshold_uncertainty_score":0.6508462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03514357767102627,"score_gpt":0.3333480467881819,"score_spread":0.2982044691171556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}