{"id":"W4400728583","doi":"10.1002/advs.202403387","title":"Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Natural Science Foundation of China; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; Jinhua Science and Technology Bureau; Zhejiang Traditional Chinese Medicine Administration; Natural Science Foundation of Zhejiang Province; Fundamental Research Funds for the Central Universities; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Spliceosome; Hepatocellular carcinoma; RNA splicing; Intron; Cancer research; Biology; Genetics; Computational biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004111811,0.000123612,0.0001530394,0.0001394896,0.0001034488,0.00005224304,0.0003454866,0.00007227489,0.000004509956],"category_scores_gemma":[0.000136649,0.0001177833,0.00009803495,0.0005562935,0.0002507551,0.00003399013,0.0001266024,0.0001057514,0.00000283025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007124108,"about_ca_system_score_gemma":0.0002297812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007457222,"about_ca_topic_score_gemma":0.00002798111,"domain_scores_codex":[0.9983824,0.00002071496,0.0002536515,0.0005967551,0.0002801332,0.0004662866],"domain_scores_gemma":[0.9994185,0.00001864919,0.0000543698,0.0002861094,0.0001164332,0.0001059338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006641505,0.00003680294,0.00411223,0.00007789747,0.000005873504,0.000003238629,0.00006911124,0.00004252982,0.9654231,0.00009209713,0.00007959871,0.02999108],"study_design_scores_gemma":[0.0004727598,0.000843159,0.001316309,0.00008599784,0.000006898374,0.000004422624,0.00008690294,0.03707896,0.9555186,0.0001785982,0.004243164,0.0001641989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934349,0.001420894,0.004048169,0.0001286761,0.0001138386,0.000728708,0.00002801518,0.00001766684,0.00007912826],"genre_scores_gemma":[0.9950407,0.000120166,0.004049233,0.00003772304,0.00006731332,0.0001569773,0.00003185888,0.00001612255,0.0004798936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03703643,"threshold_uncertainty_score":0.4803063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302084039600028,"score_gpt":0.309292949892182,"score_spread":0.2962721094961817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}