{"id":"W4400728583","doi":"10.1002/advs.202403387","title":"Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Natural Science Foundation of China; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; Jinhua Science and Technology Bureau; Zhejiang Traditional Chinese Medicine Administration; Natural Science Foundation of Zhejiang Province; Fundamental Research Funds for the Central Universities; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Spliceosome; Hepatocellular carcinoma; RNA splicing; Intron; Cancer research; Biology; Genetics; Computational biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007989852,0.0001377423,0.0001415796,0.0001187914,0.0001728566,0.0001788512,0.00008974949,0.0001307065,0.001710591],"category_scores_gemma":[0.00005659198,0.00009083262,0.0001644683,0.00008168102,0.0001501974,0.0001110506,0.0001996299,0.0002512333,0.0003137391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577477,"about_ca_system_score_gemma":0.000154658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003615689,"about_ca_topic_score_gemma":0.0005190112,"domain_scores_codex":[0.9999211,0.000007927247,0.000007525959,0.00002341419,0.00002131364,0.00001870693],"domain_scores_gemma":[0.9999505,0.000004754101,0.00001390829,0.000004384267,0.000005209913,0.00002116865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000811354,0.00001127587,0.000493382,0.00001234556,0.000001643218,0.00008327736,0.00001076026,0.00002836111,0.9984521,0.0001453412,0.00002940077,0.0006509451],"study_design_scores_gemma":[0.00001768234,0.0001743865,0.01879123,0.000003463757,0.000008956447,0.0004133368,0.00005742317,0.001645319,0.9766037,0.0001547851,0.002125485,0.000004229451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972581,0.0003432037,0.001154449,0.00005557769,0.0000172742,0.000006188191,0.0001422819,0.00004352374,0.0009793963],"genre_scores_gemma":[0.9982686,0.00008430757,0.0002868324,0.00002361601,0.00000249791,0.000005380765,0.0001526948,0.000006112296,0.001170095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001710591,"threshold_uncertainty_score":0.005722523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302084039600028,"score_gpt":0.309292949892182,"score_spread":0.2962721094961817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}