{"id":"W4400729699","doi":"10.7554/elife.93260.3.sa0","title":"Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; St. Joseph’s Healthcare Hamilton; University of British Columbia; BC Children's Hospital; University of Toronto; McMaster University; University of Alberta; Population Health Research Institute","funders":"","keywords":"Offspring; dNaM; Pregnancy; Medicine; Epigenetics; DNA methylation; Cord blood; Cohort; Demography; Cohort study; Obstetrics; Physiology; Internal medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002166885,0.000493869,0.0007116392,0.0004797728,0.0008367948,0.0009963413,0.0007205128,0.003492282,0.1109806],"category_scores_gemma":[0.02233267,0.0002311611,0.0007589409,0.0005291016,0.0006491266,0.0006519466,0.00114477,0.001998504,0.0206901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005715567,"about_ca_system_score_gemma":0.001327884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002136425,"about_ca_topic_score_gemma":0.002670901,"domain_scores_codex":[0.9983256,0.0007538016,0.0001594264,0.0003475123,0.0002588716,0.0001547013],"domain_scores_gemma":[0.9931247,0.003456956,0.0006796204,0.0002852251,0.001772526,0.0006810335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001056862,0.00003301249,0.02656128,0.0009761969,0.0001416951,0.000325996,0.0003065987,0.0001420741,0.0004353929,0.0004597356,0.9510832,0.0184779],"study_design_scores_gemma":[0.001920158,0.001147547,0.2028217,0.003954027,0.0007453589,0.003279556,0.00653098,0.001329725,0.003082276,0.00644393,0.7684441,0.0003006101],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05141034,0.007807841,0.002251568,0.7378089,0.1049088,0.0005178299,0.04512236,0.001015123,0.04915725],"genre_scores_gemma":[0.2814442,0.006186677,0.002623276,0.4836341,0.03646526,0.001911975,0.01403635,0.0006403006,0.1730579],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1109806,"threshold_uncertainty_score":0.371267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04580699464387588,"score_gpt":0.3375620058382164,"score_spread":0.2917550111943405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}