{"id":"W4400746432","doi":"10.1111/nep.14339","title":"The pathogenesis of <scp>IgAN</scp>: Where is pathogenic <scp>IgA</scp> produced?","year":2024,"lang":"en","type":"article","venue":"Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Secretory component; Immunoglobulin A; Glycosylation; Antibody; Immunology; Glycoprotein; Immune system; J chain; Pathogenesis; Biology; Immunoglobulin G; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007176374,0.0009490086,0.0008806671,0.0008431178,0.0004738155,0.001558515,0.0008220506,0.002569148,0.001784177],"category_scores_gemma":[0.0009066836,0.0002841718,0.0002974909,0.0008701223,0.002132525,0.00155565,0.0005079817,0.001165348,0.0009568139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009744258,"about_ca_system_score_gemma":0.0006643299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180488,"about_ca_topic_score_gemma":0.0004605954,"domain_scores_codex":[0.9996825,0.00009203842,0.00002628263,0.00005095366,0.00007675561,0.0000714498],"domain_scores_gemma":[0.9996829,0.00005269455,0.0001010674,0.00001883457,0.00007393474,0.00007068552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005986075,0.0009684462,0.1683286,0.01103859,0.0004349613,0.06369523,0.001842205,0.001131878,0.1866376,0.04138977,0.04903517,0.4695114],"study_design_scores_gemma":[0.0004902045,0.003030242,0.3030798,0.007294625,0.0009045618,0.2403793,0.005155839,0.01050355,0.05268994,0.06779432,0.308358,0.0003196841],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2933123,0.6653824,0.006191098,0.0185582,0.001814548,0.0001237177,0.0002910507,0.0003763688,0.01395025],"genre_scores_gemma":[0.783077,0.1992467,0.002720713,0.005096874,0.005236973,0.0000841856,0.0002907572,0.00005919554,0.004187559],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002569148,"threshold_uncertainty_score":0.007070005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062063496001538,"score_gpt":0.2547741853221638,"score_spread":0.2441535503621484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}