{"id":"W4400747878","doi":"10.1016/j.ejca.2024.114226","title":"Germline pathogenic variants of cancer predisposition genes in a multicentre Italian cohort of pancreatic cancer patients.","year":2024,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pancreas Centre (Canada)","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute","keywords":"Pancreatic cancer; Germline; Cancer; Medicine; Cohort; Oncology; Gene; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003806441,0.0001720111,0.000292297,0.0001486329,0.00002185334,0.00001638675,0.0002276958,0.00005291317,0.000197952],"category_scores_gemma":[0.00003969542,0.0001518298,0.0001609948,0.0002517085,0.00009829301,0.00001950338,0.00005879565,0.0001420123,0.000001720667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838331,"about_ca_system_score_gemma":0.0005201088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001719662,"about_ca_topic_score_gemma":0.0003683263,"domain_scores_codex":[0.9982817,0.000207995,0.0007709277,0.0002460878,0.0002973156,0.0001960083],"domain_scores_gemma":[0.9987804,0.00001606875,0.0004593232,0.0001932565,0.000476125,0.00007477011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005095718,0.0002295688,0.3558954,0.0004136042,0.001010023,0.00005843408,0.0009389577,0.008662267,0.5431541,0.00001002479,0.002080285,0.08703781],"study_design_scores_gemma":[0.002200834,0.0004722953,0.8546885,0.001629098,0.0006273318,0.0000138761,0.0001213472,0.0006257447,0.1275561,0.00001403115,0.01173548,0.0003153758],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9336376,0.06419803,0.0001965868,0.0001839082,0.0009528954,0.0002087182,0.0003707879,0.000003968642,0.0002475204],"genre_scores_gemma":[0.9866856,0.0119633,0.0003664942,0.00006824743,0.0005376074,0.00002198356,0.00002856325,0.00005189427,0.0002762666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4987931,"threshold_uncertainty_score":0.6191438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007398081677925854,"score_gpt":0.2734831380641447,"score_spread":0.2660850563862189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}