{"id":"W4400748265","doi":"10.1016/j.cgh.2024.06.037","title":"Mucosal Healing With Vedolizumab in Patients With Chronic Pouchitis: EARNEST, a Randomized, Double-Blind, Placebo-Controlled Trial","year":2024,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Mount Sinai Hospital; Western University","funders":"","keywords":"Vedolizumab; Medicine; Pouchitis; Placebo; Internal medicine; Double blind; Gastroenterology; Clinical trial; Randomized controlled trial; Ulcerative colitis; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00263267,0.001239866,0.003820443,0.0004499877,0.0005498548,0.00118038,0.0008214375,0.002043103,0.005764874],"category_scores_gemma":[0.002410045,0.0006813805,0.001605945,0.0003609605,0.001009113,0.001104599,0.0004899804,0.002067736,0.0006757246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781327,"about_ca_system_score_gemma":0.0008198255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004539181,"about_ca_topic_score_gemma":0.0008594954,"domain_scores_codex":[0.9990193,0.0005387531,0.00008653106,0.0001595296,0.00009234042,0.0001035406],"domain_scores_gemma":[0.9988715,0.0003858506,0.0002927481,0.00008508647,0.0001032052,0.0002614854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9823497,0.003126016,0.0005180379,0.001003889,0.0005796147,0.00002431094,0.00003538739,0.00007528545,0.001445631,0.00006021624,0.0003657729,0.01041607],"study_design_scores_gemma":[0.9703097,0.02755458,0.00106591,0.00004424588,0.0003387639,0.00002570172,0.00001233377,0.0001329393,0.0001475587,0.00004264717,0.000318118,0.000007404573],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760029,0.01645237,0.0007439451,0.0008658792,0.0007577785,0.002743299,0.0008517021,0.0001553419,0.001426884],"genre_scores_gemma":[0.9763106,0.00923704,0.002486598,0.001391663,0.001233026,0.005239733,0.0008895993,0.00002995874,0.003181874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005764874,"threshold_uncertainty_score":0.01928544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125673205764303,"score_gpt":0.2881884478393463,"score_spread":0.275621127262916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}