{"id":"W4400761068","doi":"10.1158/1055-9965.epi-24-0496","title":"Nonadditive Effects of Common Genetic Variants Have a Negligent Contribution to Cancer Heritability","year":2024,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Strategic Research Council; Departament d'Universitats, Recerca i Societat de la Informació; Instituto de Salud Carlos III; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; National Human Genome Research Institute; Cancer Council Victoria; School of Medicine, Vanderbilt University; National Center for Research Resources; National Institute of General Medical Sciences; Chonnam National University Hwasun Hospital; Centers for Disease Control and Prevention; DOD Prostate Cancer Research Program; Hellenic Health Foundation; Tays; Deutsche Krebshilfe; Swedish Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Vetenskapsrådet; Stockholms Läns Landsting; Servicio Gallego de Salud; Innovationsfonden; Norris Cotton Cancer Center; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Royal Marsden NHS Foundation Trust; Chonnam National University; Academy of Finland; Forskningsrådet för Arbetsliv och Socialvetenskap; Gentofte Hospital; Canary Foundation; National Institute for Health and Care Research; Karolinska Institutet; University of Cambridge; ZonMw; National Institute of Environmental Health Sciences; Prostate Cancer Canada; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; National Cancer Research Institute; Movember Foundation; Memorial Sloan-Kettering Cancer Center; Fred Hutchinson Cancer Research Center; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; U.S. Department of Defense; Cancer Research UK; Uniformed Services University of the Health Sciences; American Cancer Society; Associazione Italiana per la Ricerca sul Cancro; State of Connecticut Department of Public Health; Vanderbilt University; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; National Institute on Minority Health and Health Disparities; European Commission","keywords":"Heritability; Dominance (genetics); Biology; Genetic association; Genome-wide association study; Missing heritability problem; Genetic architecture; Additive genetic effects; Genetics; Phenotype; Genotype; Genetic variants; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004480714,0.0005773178,0.0007789603,0.00134594,0.0005034531,0.0008789046,0.0005163734,0.0003741999,0.002564103],"category_scores_gemma":[0.01908007,0.0002778097,0.001015014,0.001252138,0.00126969,0.0005432656,0.0009243689,0.000804775,0.0002175708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003642057,"about_ca_system_score_gemma":0.000520305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002928559,"about_ca_topic_score_gemma":0.003507633,"domain_scores_codex":[0.9952827,0.001739901,0.000390545,0.001369433,0.0008381954,0.0003791722],"domain_scores_gemma":[0.9787977,0.01449638,0.002684065,0.002944498,0.0006485546,0.0004288471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005432692,0.00004953492,0.9564548,0.0001416649,0.001350127,0.0006731235,0.0003266936,0.00191895,0.01303573,0.001958306,0.0001633978,0.02338447],"study_design_scores_gemma":[0.00003291782,0.0001472007,0.9850737,0.00003404122,0.0008701111,0.001580307,0.0001554054,0.003532385,0.002928984,0.004774998,0.0008466547,0.00002332908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979155,0.001348095,0.01709243,0.000194925,0.00003056079,0.00003056551,0.0004517868,0.00007591011,0.001620653],"genre_scores_gemma":[0.9981461,0.0001141863,0.001424206,0.00002769463,0.00001261733,0.000007828453,0.0001340792,0.00001137796,0.0001220067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004480714,"threshold_uncertainty_score":0.0236966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710714660633257,"score_gpt":0.3485352261663577,"score_spread":0.3314280795600251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}