{"id":"W4400763642","doi":"10.1016/s0140-6736(24)01027-4","title":"Efficacy and safety of delgocitinib cream in adults with moderate to severe chronic hand eczema (DELTA 1 and DELTA 2): results from multicentre, randomised, controlled, double-blind, phase 3 trials","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Innovaderm (Canada)","funders":"Manchester Biomedical Research Centre; LEO Pharma; National Institute for Health and Care Research","keywords":"Medicine; Delta; Physical therapy; Pediatrics; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001762907,0.0008442328,0.00234225,0.0002838533,0.0002488908,0.000855851,0.0005373089,0.001467041,0.003288983],"category_scores_gemma":[0.001685254,0.0004116934,0.002157027,0.0003118823,0.0005857914,0.0008412696,0.0002367598,0.002000597,0.0004542105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006729923,"about_ca_system_score_gemma":0.000515807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063305,"about_ca_topic_score_gemma":0.003307351,"domain_scores_codex":[0.9995222,0.0001986693,0.00004817257,0.00008873941,0.00005953819,0.00008267842],"domain_scores_gemma":[0.9992156,0.0003337608,0.0002430411,0.00003093341,0.00005609818,0.0001205807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8639014,0.002805088,0.002357917,0.008689052,0.004894679,0.0001116353,0.0001498927,0.0006111981,0.007484115,0.0001848963,0.003138721,0.1056713],"study_design_scores_gemma":[0.9207442,0.06100135,0.01087559,0.0004575127,0.00265914,0.0002124493,0.00007402557,0.000394577,0.0009275042,0.0002167343,0.002400995,0.00003589221],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.885542,0.1062212,0.0005642455,0.001336028,0.0005888041,0.001289665,0.001157073,0.0001049287,0.003195993],"genre_scores_gemma":[0.9753264,0.0192102,0.000656724,0.001373726,0.0002856715,0.0006482282,0.0007557758,0.00001354529,0.001729736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003288983,"threshold_uncertainty_score":0.01100272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04159514814402164,"score_gpt":0.32357189582103,"score_spread":0.2819767476770083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}