{"id":"W4400770098","doi":"10.1002/advs.202400720","title":"A Damaging <i>COL6A3</i> Variant Alters the <i>MIR31HG</i> ‐Regulated Response of Chondrocytes in Neocartilage Organoids to Hyperphysiologic Mechanical Loading","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; ZonMw; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Delta; Leids Universitair Medisch Centrum; Universiteit Leiden; Arthritis Society; Pfizer; Shriners Hospitals for Children; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society","keywords":"Cell biology; Epigenetics; Chondrocyte; Mechanotransduction; Chemistry; Phenotype; Cancer research; Gene; Biology; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182413,0.0002784305,0.0001544231,0.0001544988,0.0001783674,0.0002339486,0.0001523142,0.0003409648,0.00203111],"category_scores_gemma":[0.0001271496,0.0001365645,0.0002882366,0.0001305828,0.0002960754,0.00009433587,0.000160583,0.0004477708,0.0005811728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496087,"about_ca_system_score_gemma":0.000173655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290145,"about_ca_topic_score_gemma":0.002004981,"domain_scores_codex":[0.9998047,0.00002524115,0.00002176749,0.00005321008,0.00006376301,0.00003127233],"domain_scores_gemma":[0.9998708,0.00002208009,0.00005247956,0.00001636989,0.000007389952,0.00003088693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006200068,0.000007004333,0.0001202933,0.00001254389,0.000003541906,0.00005581905,0.00000578648,0.00004334879,0.9992533,0.00003622688,0.00003966794,0.0003605217],"study_design_scores_gemma":[0.00001777021,0.0001847999,0.009900561,0.000005304854,0.00002247621,0.0006087238,0.00003448031,0.00114456,0.9852709,0.00007033821,0.002730088,0.00001008187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902791,0.0007114073,0.004680844,0.0001958071,0.0001044516,0.00003408228,0.001648588,0.0002813007,0.002064311],"genre_scores_gemma":[0.9944474,0.0002645574,0.001965516,0.0001238936,0.000007986002,0.00002636468,0.0007091314,0.00005656406,0.002398719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203111,"threshold_uncertainty_score":0.006794751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008054533646248,"score_gpt":0.275536187392014,"score_spread":0.2654556420555515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}