{"id":"W4400775374","doi":"10.1016/j.str.2024.06.017","title":"Structural insights into an atypical histone binding mechanism by a PHD finger","year":2024,"lang":"en","type":"article","venue":"Structure","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PHD finger; Zinc finger; H3K4me3; Histone; Histone methyltransferase; Mechanism (biology); Protein subunit; Computational biology; Biology; Cell biology; Genetics; Biochemistry; DNA; Transcription factor; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002247845,0.000205455,0.0002877087,0.0001072287,0.0003522226,0.0004457858,0.0007191899,0.0005109514,0.00235479],"category_scores_gemma":[0.000219811,0.0002313174,0.0002253757,0.0001067241,0.0003494997,0.0006664079,0.0002887584,0.0007244715,0.0004766129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003779563,"about_ca_system_score_gemma":0.0002057053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004295687,"about_ca_topic_score_gemma":0.000472914,"domain_scores_codex":[0.9999166,0.000007208129,0.000004721772,0.00002660998,0.0000266418,0.00001809523],"domain_scores_gemma":[0.9998963,0.00002882069,0.00001660744,0.00001626368,0.000009441791,0.00003261871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002969382,0.00004659593,0.0009185379,0.00005928731,0.00001504363,0.0004423392,0.00004294814,0.00234435,0.982182,0.00869323,0.0002709425,0.004687909],"study_design_scores_gemma":[0.0001363417,0.0002385752,0.006512735,0.000009414423,0.00003861802,0.001608477,0.000144956,0.05969737,0.9124892,0.01046272,0.008602937,0.00005868436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633964,0.0005891974,0.03237747,0.0005265453,0.00006657741,0.00001689718,0.0001554027,0.0003229814,0.002548375],"genre_scores_gemma":[0.9937187,0.0001493607,0.004643439,0.00007887259,0.00001308724,0.000005130034,0.00006707741,0.00001176119,0.001312658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00235479,"threshold_uncertainty_score":0.007877588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005053053805313344,"score_gpt":0.2387154113491462,"score_spread":0.2336623575438328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}