{"id":"W4400777194","doi":"10.1021/acs.jmedchem.4c00629","title":"Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Masarykova Univerzita; Agentura Pro Zdravotnický Výzkum České Republiky; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; European Commission; Bader Philanthropies","keywords":"Chemistry; SMAD; Kinase; Bone morphogenetic protein; BMPR2; Signal transduction; Activin receptor; Protein-Serine-Threonine Kinases; Cell biology; Receptor; ACVR2B; Bone morphogenetic protein 2; Biochemistry; Protein kinase A; TGF beta signaling pathway; Biology; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686738,0.0001137751,0.0003093268,0.00006058453,0.00002886185,0.00001950986,0.00006491713,0.0001089162,0.00007943792],"category_scores_gemma":[0.0001855584,0.00007687433,0.0001376788,0.0001112044,0.0001412631,0.0001302385,0.00001290088,0.0004235181,4.831724e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009139078,"about_ca_system_score_gemma":0.0004022856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001812557,"about_ca_topic_score_gemma":2.017425e-7,"domain_scores_codex":[0.9990183,0.00001250704,0.0004247641,0.0001396977,0.0002837708,0.0001209526],"domain_scores_gemma":[0.9992142,0.0001843507,0.0001795216,0.00008043036,0.0002166212,0.000124834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002769011,0.00006828231,0.000443386,0.0007888339,0.0002765222,0.00003667634,0.0002170429,7.709168e-7,0.9913394,0.0001739822,0.002511978,0.003866262],"study_design_scores_gemma":[0.001971584,0.0003498668,0.001186863,0.001571231,0.0004146502,0.002043627,0.0003214481,0.00009629635,0.9872528,0.0007023123,0.003981526,0.0001077827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946611,0.001412339,0.0003978,0.002609219,0.0002245689,0.0001546087,0.00002895239,0.00001314912,0.0004982522],"genre_scores_gemma":[0.9973421,0.0001257894,0.000790685,0.00007121253,0.0006733339,0.000008479431,0.00002425437,0.00001200478,0.0009521898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004086548,"threshold_uncertainty_score":0.3134844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116483346780392,"score_gpt":0.3018784574782613,"score_spread":0.290230122800222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}