{"id":"W4400782574","doi":"10.1021/acsami.4c08240","title":"Cell Membrane-Derived Nanoparticles as Biomimetic Nanotherapeutics to Alleviate Fatty Liver Disease","year":2024,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada; Government of Ontario","keywords":"Bioavailability; Drug delivery; Hepatocyte; Drug; Materials science; Cell; Rosuvastatin; Pharmacology; Nanotechnology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002237156,0.0003020686,0.0003526142,0.000124205,0.0001405119,0.000211811,0.0002955378,0.000158196,0.001906901],"category_scores_gemma":[0.00001150658,0.000249288,0.00003557461,0.0001286051,0.0001283349,0.0001229857,0.0001855946,0.00008840334,0.006982231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004409946,"about_ca_system_score_gemma":0.00005095249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006401855,"about_ca_topic_score_gemma":0.000003428228,"domain_scores_codex":[0.9985053,0.0001156425,0.0004293946,0.0004794192,0.00005951949,0.0004107021],"domain_scores_gemma":[0.9994087,0.00008268814,0.0000819089,0.00034607,0.00003406362,0.00004663605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005043537,0.00009584767,0.00000328275,0.0001412496,0.0001663054,0.0000057515,0.0007774044,0.00001706422,0.9935138,0.001216389,0.0006653029,0.002893244],"study_design_scores_gemma":[0.0004281962,0.0001080128,0.0003418462,0.00009599705,0.000133358,0.000006482591,0.00008955133,0.000001027249,0.9870977,0.0002969445,0.01109699,0.000303828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883644,0.008850515,0.00003685636,0.0003899483,0.001182009,0.0005372763,0.00008434882,0.0002478825,0.0003067622],"genre_scores_gemma":[0.997431,0.0005120428,0.0000737065,0.0004247361,0.00004824099,0.0001217575,0.00007529484,0.00005528819,0.001257979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01043169,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148984201993471,"score_gpt":0.2435277672532402,"score_spread":0.2286293470538931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}