{"id":"W4400782574","doi":"10.1021/acsami.4c08240","title":"Cell Membrane-Derived Nanoparticles as Biomimetic Nanotherapeutics to Alleviate Fatty Liver Disease","year":2024,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada; Government of Ontario","keywords":"Bioavailability; Drug delivery; Hepatocyte; Drug; Materials science; Cell; Rosuvastatin; Pharmacology; Nanotechnology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009849956,0.0002307926,0.0002454963,0.0001658206,0.00007729411,0.0001616928,0.0001396772,0.000377009,0.0003821828],"category_scores_gemma":[0.00009025396,0.00009673793,0.0002146469,0.00008139783,0.0001198404,0.0002179042,0.0002000087,0.0003461292,0.0002190758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306604,"about_ca_system_score_gemma":0.0001057332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003047832,"about_ca_topic_score_gemma":0.0005628486,"domain_scores_codex":[0.9999336,0.00001238853,0.000005506986,0.0000147468,0.00001928642,0.00001444781],"domain_scores_gemma":[0.9999698,0.000004560657,0.000009600664,0.000002894595,0.000007668434,0.000005407986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003156978,0.00001441019,0.00003141933,0.00007914048,0.000005248794,0.00003218617,0.00001042721,0.0001957185,0.9962443,0.0001311851,0.00005735414,0.003167073],"study_design_scores_gemma":[0.00001448765,0.0002028723,0.0003867621,0.00001050598,0.00002144221,0.0001247456,0.00001342531,0.002031688,0.9905839,0.00006104339,0.006542004,0.000007014881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416792,0.01960351,0.03337604,0.0005159926,0.0002591029,0.0001453345,0.0002795427,0.0003506926,0.00379061],"genre_scores_gemma":[0.9796485,0.005391546,0.0119378,0.0001792763,0.00002882713,0.00008760147,0.0001685274,0.00003413175,0.002523678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003821828,"threshold_uncertainty_score":0.00167352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148984201993471,"score_gpt":0.2435277672532402,"score_spread":0.2286293470538931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}