{"id":"W4400786995","doi":"10.1038/s41419-024-06893-2","title":"Targeting valine catabolism to inhibit metabolic reprogramming in prostate cancer","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Queensland University of Technology; Australian Government","keywords":"Lipogenesis; Prostate cancer; LNCaP; Catabolism; Biology; Biochemistry; Downregulation and upregulation; Valine; Lipid metabolism; Metabolism; Chemistry; Cell biology; Cancer research; Cancer; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159987,0.0001796072,0.0001665977,0.0000896921,0.00005633338,0.00008485886,0.0000787168,0.00004958036,0.00001724547],"category_scores_gemma":[0.00008143707,0.0001666481,0.00006948372,0.0001815339,0.00002769255,0.000008980358,0.0001096324,0.00009022601,0.000009053761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000866418,"about_ca_system_score_gemma":0.0002392493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002991325,"about_ca_topic_score_gemma":0.00005036715,"domain_scores_codex":[0.998744,0.00002944534,0.000199438,0.0005678977,0.0001026028,0.0003566696],"domain_scores_gemma":[0.9991847,0.000005851638,0.00002425379,0.0002207689,0.00003789745,0.0005265305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009393021,0.000330003,0.0335883,0.001135477,0.00009667228,0.0001677182,0.001597826,0.001720899,0.7253844,0.0008964929,0.0256905,0.2084525],"study_design_scores_gemma":[0.0006347956,0.00002806081,0.005475543,0.00007020294,0.00009868338,0.00000271269,0.00007808342,0.0003138256,0.02124612,0.0001668643,0.9715353,0.0003498164],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7414759,0.2568455,0.0001153891,0.0002480647,0.0006970147,0.0003123857,0.00011331,0.00002769742,0.0001647742],"genre_scores_gemma":[0.9787551,0.01586276,0.0003785292,0.0007644573,0.001733302,0.0002161768,0.0001842525,0.0000389149,0.002066514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9458448,"threshold_uncertainty_score":0.6795711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007845208853114268,"score_gpt":0.2607683284660319,"score_spread":0.2529231196129176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}