{"id":"W4400797315","doi":"10.1097/tp.0000000000005108","title":"Scalable Bioreactor-based Suspension Approach to Generate Stem Cell–derived Islets From Healthy Donor-derived iPSCs","year":2024,"lang":"en","type":"article","venue":"Transplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada); University of Alberta","funders":"Breakthrough T1D Canada","keywords":"PDX1; Induced pluripotent stem cell; Cell biology; Cellular differentiation; SOX2; Transplantation; Islet; Directed differentiation; Biology; Chemistry; Medicine; Embryonic stem cell; Biochemistry; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004634594,0.0006895669,0.0003361962,0.0005657657,0.0001951567,0.0006259233,0.0005607255,0.0005525298,0.001581075],"category_scores_gemma":[0.0001704341,0.0001934949,0.000509233,0.0001971899,0.0003043303,0.0002753122,0.0004507105,0.00101144,0.0009108541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000459089,"about_ca_system_score_gemma":0.0003578905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349913,"about_ca_topic_score_gemma":0.0009695626,"domain_scores_codex":[0.9997115,0.00002584047,0.00003388965,0.00006344784,0.0001415711,0.00002376103],"domain_scores_gemma":[0.9998481,0.00002676207,0.00003996008,0.00002184692,0.00003577229,0.00002752308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001813849,0.0000287283,0.0001532745,0.00003595903,0.000005625706,0.00004794526,0.00001534987,0.0003344091,0.9966699,0.00008669025,0.00009502383,0.002508926],"study_design_scores_gemma":[0.00001719861,0.0002411306,0.001119433,0.0000140592,0.00003341202,0.0002008238,0.00002683004,0.004522309,0.990027,0.0001100831,0.00367581,0.00001189227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7338817,0.004029766,0.2513527,0.0007102168,0.0002799141,0.0007788081,0.001313013,0.001822431,0.005831455],"genre_scores_gemma":[0.8530226,0.002765179,0.1356351,0.0002926232,0.0000789284,0.0004648148,0.002184506,0.0001638793,0.005392278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581075,"threshold_uncertainty_score":0.005289197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03109834610120096,"score_gpt":0.2554771168045053,"score_spread":0.2243787707033043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}