{"id":"W4400803517","doi":"10.1007/s11357-024-01276-z","title":"Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant","year":2024,"lang":"en","type":"article","venue":"GeroScience","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mitochondrial fission; Mitophagy; Biology; Mitochondrion; Cell biology; mitochondrial fusion; Gene knockdown; Mitochondrial DNA; RNA interference; Caenorhabditis elegans; Mutant; Genetics; Gene; RNA; Apoptosis; Autophagy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963383,0.0001295607,0.0001146189,0.0000276978,0.000163372,0.00003536517,0.0005313289,0.00009334586,0.00003134302],"category_scores_gemma":[0.0001164749,0.00007686257,0.000101495,0.0002340746,0.0004556699,0.000008213527,0.000309015,0.000104462,0.000006724169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002394323,"about_ca_system_score_gemma":0.000212995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000260778,"about_ca_topic_score_gemma":0.00002380973,"domain_scores_codex":[0.9987984,0.00007237425,0.0002616754,0.0003542908,0.0003151175,0.0001981301],"domain_scores_gemma":[0.9994588,0.00001809787,0.00009905844,0.0003268673,0.00005122133,0.00004598749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001800453,0.00003850578,0.0004622252,0.00002389485,0.000007989571,4.0164e-7,0.0007749696,0.00006856184,0.994508,0.00003317045,0.0004032986,0.003660985],"study_design_scores_gemma":[0.0001230232,0.0001075671,0.01067538,0.00003730542,0.00001484589,0.00001470474,0.0001120486,0.0003412251,0.98348,0.00009579016,0.004886328,0.0001117303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894781,0.0006859589,0.007925261,0.0002448573,0.001292041,0.0001959377,0.00005005333,0.000009138544,0.0001186721],"genre_scores_gemma":[0.99677,0.0002597599,0.002238909,0.00008766569,0.0001783222,0.000008609284,0.00001015857,0.00001215622,0.000434478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102795,"threshold_uncertainty_score":0.3134365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231487323023416,"score_gpt":0.243943682755934,"score_spread":0.2316288095256998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}