{"id":"W4400808603","doi":"10.3390/biom14070864","title":"TRAF1 Deficiency in Macrophages Drives Exacerbated Joint Inflammation in Rheumatoid Arthritis","year":2024,"lang":"en","type":"article","venue":"Biomolecules","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Inflammation; Inflammasome; Immunology; Rheumatoid arthritis; Cytokine; Tumor necrosis factor alpha; Immune system; Pathogenesis; Arthritis; Macrophage; Medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298779,0.0001769098,0.0001523697,0.0002339968,0.00002969689,0.00007524179,0.0001319482,0.0001302302,0.0000237479],"category_scores_gemma":[0.00006844496,0.000180113,0.00007043725,0.0003375631,0.0001042486,0.00000888899,0.00006755654,0.0001037286,0.00004803612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003358512,"about_ca_system_score_gemma":0.00009102144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000903076,"about_ca_topic_score_gemma":0.0005080452,"domain_scores_codex":[0.9987116,0.00008860655,0.0003557907,0.0004233901,0.0001346424,0.0002859459],"domain_scores_gemma":[0.9996624,0.00001152921,0.00004096429,0.0002111889,0.00002695215,0.00004696807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001372033,0.00003602896,0.0004656721,0.0000432144,0.000007627626,0.0001274363,0.0002081084,0.0001024748,0.9846802,0.0004783775,0.0002233997,0.01361376],"study_design_scores_gemma":[0.0004221278,0.00009506594,0.003365221,0.0002782558,0.000001737621,0.0000416396,0.00009438111,0.0005232853,0.991576,0.0002349148,0.003130046,0.0002373349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970831,0.02670198,0.001229926,0.0001976036,0.0001611027,0.0001892788,0.00001972303,0.0000539438,0.0006153738],"genre_scores_gemma":[0.9968212,0.002367373,0.0004859186,0.00002937182,0.00005307361,0.00003974415,0.0001056617,0.00003021698,0.00006738664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02599019,"threshold_uncertainty_score":0.7344796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009882541040985755,"score_gpt":0.2357956751245408,"score_spread":0.2259131340835551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}