{"id":"W4400808603","doi":"10.3390/biom14070864","title":"TRAF1 Deficiency in Macrophages Drives Exacerbated Joint Inflammation in Rheumatoid Arthritis","year":2024,"lang":"en","type":"article","venue":"Biomolecules","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Inflammation; Inflammasome; Immunology; Rheumatoid arthritis; Cytokine; Tumor necrosis factor alpha; Immune system; Pathogenesis; Arthritis; Macrophage; Medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003114393,0.0006799249,0.0004420159,0.0006556688,0.0002967876,0.0004301061,0.000275048,0.0006426512,0.002258248],"category_scores_gemma":[0.0001609669,0.0003365748,0.0003731348,0.0002573053,0.0006239854,0.0002886202,0.0003481172,0.001028106,0.0009064608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003401876,"about_ca_system_score_gemma":0.0002705939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000396468,"about_ca_topic_score_gemma":0.0006858518,"domain_scores_codex":[0.999537,0.00009999525,0.0000521275,0.0001009267,0.0001046399,0.0001054534],"domain_scores_gemma":[0.9997081,0.00003096286,0.0001158548,0.00002923606,0.00002023079,0.00009556963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473913,0.00005133339,0.0001717617,0.00002527117,0.000003971224,0.000112229,0.0000175588,0.0000244536,0.9990426,0.00006272582,0.00001778591,0.0003228921],"study_design_scores_gemma":[0.0001089524,0.001067792,0.01142862,0.00003412831,0.00004302353,0.002453704,0.000184438,0.0008676677,0.9811148,0.0002714049,0.002405624,0.00001979797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948351,0.001645491,0.001922496,0.0001844335,0.00006425146,0.00003193599,0.0003033021,0.0000816567,0.00093127],"genre_scores_gemma":[0.9940783,0.0008958579,0.001592779,0.00007753458,0.00001983276,0.0000439902,0.0001934594,0.00003010257,0.00306827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002258248,"threshold_uncertainty_score":0.007554591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009882541040985755,"score_gpt":0.2357956751245408,"score_spread":0.2259131340835551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}