{"id":"W4400809745","doi":"10.1126/sciadv.ado5264","title":"Huntingtin is an RNA binding protein and participates in <i>NEAT1</i> -mediated paraspeckles","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Hospital for Sick Children; Princess Margaret Cancer Centre; BC Children's Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Genentech; Ontario Genomics Institute; Merck KGaA; Ontario Genomics; Genome Canada; Mitacs; Michael Smith Health Research BC; BC Children's Hospital; Massachusetts General Hospital; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Huntingtin; RNA; Biology; Huntingtin Protein; Nucleic acid; Cell biology; Gene knockdown; Mutant; RNA-binding protein; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104551,0.0003259848,0.0001793716,0.000174469,0.0002801362,0.0003182337,0.0001882846,0.0002742595,0.001288159],"category_scores_gemma":[0.0001963065,0.000161236,0.0002783391,0.00009355113,0.0001810664,0.000238001,0.0002937093,0.0002913023,0.0007133625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172586,"about_ca_system_score_gemma":0.00009941004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005416331,"about_ca_topic_score_gemma":0.001017088,"domain_scores_codex":[0.9998443,0.00001627367,0.00001184451,0.00005879927,0.00004711947,0.00002165639],"domain_scores_gemma":[0.9998729,0.0000193596,0.00004959245,0.00001134146,0.00001225965,0.00003450784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004301099,0.000005372573,0.0006803143,0.00003488195,0.000006778369,0.0001781075,0.00001770596,0.00004611106,0.9975629,0.000126125,0.00006069583,0.001237963],"study_design_scores_gemma":[0.00001300273,0.0001734713,0.04464487,0.00002016889,0.00002704704,0.001989003,0.00007393287,0.002622681,0.9442219,0.0003378925,0.005859779,0.00001616683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892983,0.001669442,0.006211687,0.00007332556,0.00003605459,0.00002136983,0.0003615987,0.0001534855,0.002174704],"genre_scores_gemma":[0.9904398,0.0004607655,0.004822419,0.00008339016,0.00001294055,0.00001714788,0.0008634061,0.00004462626,0.003255379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288159,"threshold_uncertainty_score":0.004309297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04232358663640947,"score_gpt":0.3285866005345879,"score_spread":0.2862630138981784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}