{"id":"W4400813247","doi":"10.1080/03007995.2024.2378172","title":"Why fexofenadine is considered as a truly non-sedating antihistamine with no brain penetration: a systematic review","year":2024,"lang":"en","type":"review","venue":"Current Medical Research and Opinion","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Sanofi-Aventis Deutschland; Sanofi","keywords":"Fexofenadine; Medicine; Antihistamine; Sedation; Sedative; Histamine H1 receptor; Cetirizine; Pharmacology; Histamine H1 Antagonists; Terfenadine; Psychomotor learning; Histamine; Anesthesia; Cognition; Internal medicine; Receptor; Antagonist; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003031459,0.0004882425,0.002824696,0.0004244977,0.0002021802,0.0001564594,0.0001980428,0.0003444864,0.000749959],"category_scores_gemma":[0.007887525,0.0002836295,0.0002454059,0.0009696571,0.0003570456,0.00009177717,0.000159152,0.001776659,0.0004491081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698353,"about_ca_system_score_gemma":0.002373792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003878201,"about_ca_topic_score_gemma":0.00001281339,"domain_scores_codex":[0.9938449,0.0006508325,0.001333465,0.0008233915,0.002768626,0.0005787789],"domain_scores_gemma":[0.9962118,0.001193345,0.0002909594,0.0005374189,0.0008120498,0.000954474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0000187377,0.00007395491,4.205027e-7,0.7363933,0.0001603848,0.0002334368,0.00005851133,9.334912e-10,1.027948e-7,0.0002211354,0.1821579,0.08068214],"study_design_scores_gemma":[0.0003686268,0.0005440819,2.890917e-7,0.5241634,0.0003771904,0.000823373,0.00001698231,0.0001663366,8.817638e-8,0.00001956839,0.4733713,0.0001488426],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002118486,0.9873512,0.0001598257,0.006075436,0.000494923,0.004520967,0.00003814889,0.00004794908,0.001309442],"genre_scores_gemma":[0.000009463905,0.9945906,0.00004582662,0.001408854,0.0008735615,0.0003284549,0.001592244,0.00006977522,0.001081196],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2912134,"threshold_uncertainty_score":0.9999616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1428743644642795,"score_gpt":0.4764002640019995,"score_spread":0.33352589953772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}